Simplex Lattice Design and Machine Learning Methods for the Optimization of Novel Microemulsion Systems to Enhance p-Coumaric Acid Oral Bioavailability: In Vitro and In Vivo Studies

被引:0
作者
Nayera Nasser
Rania M. Hathout
Hend Abd-Allah
Omaima A. Sammour
机构
[1] Ain Shams University,Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy
来源
AAPS PharmSciTech | / 25卷
关键词
cytotoxicity; microemulsions; p-coumaric acid; re-dispersibility;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 296 条
[61]  
Guinedi AS(2019)Loratadine self-microemulsifying drug delivery systems (SMEDDS) in combination with sulforaphane for the synergistic chemoprevention of pancreatic cancer Drug Deliv Transl Res. 9 641-2337
[62]  
Mortada ND(2018)Preparation of curcuminoid microemulsions from: Curcuma longa L to enhance inhibition effects on growth of colon cancer cells HT-29 R Soc Chem Adv. 8 2323-424
[63]  
Mansour S(2020)Paclitaxel loaded EDC-crosslinked fibroin nanoparticles: a potential approach for colon cancer treatment Drug Deliv Transl Res. 10 413-1227
[64]  
Hathout RM(2014)Flavonoids loaded in nanocarriers: an opportunity to increase oral bioavailability and bioefficacy Food Nutr Sci. 5 1212-486
[65]  
Nasser N(2005)Effect of self-microemulsifying drug delivery systems containing Labrasol on tight junctions in Caco-2 cells Eur J Pharm Sci. 24 477-13239
[66]  
Hathout RM(2015)The enhanced inhibitory effect of different antitumor agents in self-microemulsifying drug delivery systems on human cervical cancer HeLa cells Molecules. 20 13226-678
[67]  
Abd-Allah H(2010)Development of silymarin self-microemulsifying drug delivery system with enhanced oral bioavailability Am Assoc Pharm Sci. 11 672-18
[68]  
Sammour OA(2018)Targeted inhibitors of P-glycoprotein increase chemotherapeutic-induced mortality of multidrug resistant tumor cells Sci Rep. 8 1-897
[69]  
Subongkot T(2019)High-throughput screening of excipients with a biological effect: a kinetic study on the effects of surfactants on efflux-mediated transport J Pharm Pharmacol. 71 889-573
[70]  
Ngawhirunpat T(2012)Evaluation of cytotoxicity of surfactants used in self-micro emulsifying drug delivery systems and their effects on paracellular transport in Caco-2 cell monolayer Eur J Pharm Sci. 47 564-11