Dissolution of a Biopharmaceutics Classification System Class II Free Acid from Immediate Release Tablets Containing a Microenvironmental pH Modulator: Comparison of a Biorelevant Bicarbonate Buffering System with Phosphate Buffers

被引:0
作者
Dorota Haznar-Garbacz
Dagmara Hoc
Grzegorz Garbacz
Marek Lachman
Daria Słomińska
Michał Romański
机构
[1] Wroclaw Medical University,Department of Drug Form Technology
[2] Physiolution Polska,Department of Pharmacology
[3] Physiolution GmbH,Department of Physical Pharmacy and Pharmacokinetics
[4] Budenheim KG,undefined
[5] Poznan University of Medical Sciences,undefined
[6] Poznan University of Medical Sciences,undefined
来源
AAPS PharmSciTech | / 23卷
关键词
dissolution model; microenvironmental pH modulators; supersaturation; weak acid;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 110 条
[1]  
Bermejo M(2020)Mechanistic physiologically-based biopharmaceutics modeling (PBBM) approach to assess the in vivo performance of an orally administered drug product: From IVIVC to IVIVP Pharmaceutics 12 74-4304
[2]  
Hens B(2017)In vivo dissolution and systemic absorption of immediate release ibuprofen in human gastrointestinal tract under fed and fasted conditions Mol Pharm 14 4295-163
[3]  
Dickens J(2014)The Biopharmaceutics Classification System: subclasses for in vivo predictive dissolution (IPD) methodology and IVIVC Eur J Pharm Sci 57 152-338
[4]  
Mudie D(2017)Investigation of the effect of solubility increase at the main absorption site on bioavailability of BCS class II drug (risperidone) using liquisolid technique Drug Deliv 24 328-392
[5]  
Paixão P(2018)Amorphous solid dispersions and nanocrystal technologies for poorly water-soluble drug delivery – an update Int J Pharmaceutics 535 379-175
[6]  
Tsume Y(2020)The potential of nanofibers to increase solubility and dissolution rate of the poorly soluble and chemically unstable drug lovastatin Int J Pharmaceutics 573 167-17
[7]  
Sun D(2020)Impact of nanoparticle size and solid state on dissolution rate by investigating modified drug powders Powder Technol 376 12-1617
[8]  
Baker JR(2012)Improvement in solubility of poor water-soluble drugs by solid dispersion Int J Pharm Investig 2 1607-1344
[9]  
Wen B(2011)Physical stability of salts of weak bases in the solid-state J Pharm Sci 100 1334-556
[10]  
Frances A(2014)Combined use of crystalline sodium salt and polymeric precipitation inhibitors to improve pharmacokinetic profile of ibuprofen through supersaturation AAPS PharmSciTech 15 536-356