An Auristatin nanoconjugate targeting CXCR4+ leukemic cells blocks acute myeloid leukemia dissemination

[1] Spoo AC(2007)CXCR4 is a prognostic marker in acute myelogenous leukemia Blood. 109 786-791

[2] Lübbert M(2007)The CXCR4 chemokine receptor in acute and chronic leukaemia: a marrow homing receptor and potential therapeutic target Br J Haematol 137 288-296

[3] Wierda WG(2013)CXC chemokine receptor 4 expression, CXC chemokine receptor 4 activation, and wild-type nucleophosmin are independently associated with unfavorable prognosis in patients with acute myeloid leukemia Clin Lymphoma Myeloma Leuk 13 686-692

[4] Burger JA(2017)Targeting the CXCL12/CXCR4 axis in acute myeloid leukemia: from bench to bedside Korean J Intern Med 32 248-257

[5] Burger JA(2015)Normal and leukemic stem cell niches: insights and therapeutic opportunities Cell Stem Cell 16 254-267

[6] Bürkle A(2012)CXCR4 inhibitors selectively eliminate CXCR4-expressing human acute myeloid leukemia cells in NOG mouse model Cell Death Dis 3 e396-1512

[7] Konoplev S(2009)CXCR4 expression and biologic activity in acute myeloid leukemia are dependent on oxygen partial pressure Blood. 113 1504-383

[8] Lin P(2018)Dual Targeting of Acute Leukemia and Supporting Niche by CXCR4-Directed Theranostics Theranostics. 8 369-39

[9] Yin CC(2013)Role of CXCR4 in the pathogenesis of acute myeloid leukemia Theranostics. 3 34-390

[10] Lin E(2008)Cancer stem cells: implications for the progression and treatment of metastatic disease J Cell Mol Med 12 374-3839

[1] Spoo AC(2007)CXCR4 is a prognostic marker in acute myelogenous leukemia Blood. 109 786-791

[2] Lübbert M(2007)The CXCR4 chemokine receptor in acute and chronic leukaemia: a marrow homing receptor and potential therapeutic target Br J Haematol 137 288-296

[3] Wierda WG(2013)CXC chemokine receptor 4 expression, CXC chemokine receptor 4 activation, and wild-type nucleophosmin are independently associated with unfavorable prognosis in patients with acute myeloid leukemia Clin Lymphoma Myeloma Leuk 13 686-692

[4] Burger JA(2017)Targeting the CXCL12/CXCR4 axis in acute myeloid leukemia: from bench to bedside Korean J Intern Med 32 248-257

[5] Burger JA(2015)Normal and leukemic stem cell niches: insights and therapeutic opportunities Cell Stem Cell 16 254-267

[6] Bürkle A(2012)CXCR4 inhibitors selectively eliminate CXCR4-expressing human acute myeloid leukemia cells in NOG mouse model Cell Death Dis 3 e396-1512

[7] Konoplev S(2009)CXCR4 expression and biologic activity in acute myeloid leukemia are dependent on oxygen partial pressure Blood. 113 1504-383

[8] Lin P(2018)Dual Targeting of Acute Leukemia and Supporting Niche by CXCR4-Directed Theranostics Theranostics. 8 369-39

[9] Yin CC(2013)Role of CXCR4 in the pathogenesis of acute myeloid leukemia Theranostics. 3 34-390

[10] Lin E(2008)Cancer stem cells: implications for the progression and treatment of metastatic disease J Cell Mol Med 12 374-3839