Histone H3 wild-type DIPG/DMG overexpressing EZHIP extend the spectrum diffuse midline gliomas with PRC2 inhibition beyond H3-K27M mutation

被引:0
|
作者
David Castel
Thomas Kergrohen
Arnault Tauziède-Espariat
Alan Mackay
Samia Ghermaoui
Emmanuèle Lechapt
Stefan M. Pfister
Christof M. Kramm
Nathalie Boddaert
Thomas Blauwblomme
Stéphanie Puget
Kévin Beccaria
Chris Jones
David T. W. Jones
Pascale Varlet
Jacques Grill
Marie-Anne Debily
机构
[1] Université Paris-Saclay,Molecular Predictors and New Targets in Oncology, INSERM, Gustave Roussy
[2] Université Paris-Saclay,Département de Cancérologie de l’Enfant et de l’Adolescent, Gustave Roussy
[3] GHU Paris Psychiatrie Neurosciences,Department of Neuropathology
[4] Sainte-Anne Hospital,Divisions of Molecular Pathology
[5] Université de Paris,Division of Pediatric Neurooncology (B062)
[6] The Institute of Cancer Research,Department of Pediatric Hematology and Oncology
[7] Hopp Children’s Cancer Center Heidelberg (KiTZ),Division of Pediatric Hematology and Oncology
[8] German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK),Department of Pediatric Radiology, IMAGINE Institute, INSERM UMR 1163, INSERM U1000, Hôpital Necker
[9] Heidelberg University Hospital,Enfants Malades
[10] University Medical Center Goettingen,Department of Pediatric Neurosurgery, Hôpital Necker
[11] Université de Paris,Enfants Malades, APHP
[12] Université de Paris,Pediatric Glioma Research Group
[13] German Cancer Research Center (DKFZ),Département de Biologie, Univ. Evry
[14] Université Paris-Saclay,undefined
来源
Acta Neuropathologica | 2020年 / 139卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:1109 / 1113
页数:4
相关论文
共 50 条
  • [1] HISTONE H3 WILD-TYPE DIPG/DMG OVEREXPRESSING EZHIP EXTEND THE SPECTRUM OF DIFFUSE MIDLINE GLIOMAS WITH PRC2 INHIBITION BEYOND H3-K27M MUTATION
    Castel, David
    Kergrohen, Thomas
    Tauziede-Espariat, Arnault
    Mackay, Alan
    Ghermaoui, Samia
    Lechapt, Emmanuele
    Pfister, Stefan
    Kramm, Christof
    Boddaert, Nathalie
    Blauwblomme, Thomas
    Puget, Stephanie
    Beccaria, Kevin
    Jones, Chris
    Jones, David
    Varlet, Pascale
    Grill, Jacques
    Debily, Marie-Anne
    NEURO-ONCOLOGY, 2020, 22 : 298 - 298
  • [2] Histone H3 wild-type DIPG/DMG overexpressing EZHIP extend the spectrum diffuse midline gliomas with PRC2 inhibition beyond H3-K27M mutation
    Castel, David
    Kergrohen, Thomas
    Tauziede-Espariat, Arnault
    Mackay, Alan
    Ghermaoui, Samia
    Lechapt, Emmanuele
    Pfister, Stefan M.
    Kramm, Christof M.
    Boddaert, Nathalie
    Blauwblomme, Thomas
    Puget, Stephanie
    Beccaria, Kevin
    Jones, Chris
    Jones, David T. W.
    Varlet, Pascale
    Grill, Jacques
    Debily, Marie-Anne
    ACTA NEUROPATHOLOGICA, 2020, 139 (06) : 1109 - 1113
  • [3] Imaging Characteristics of Pediatric Diffuse Midline Gliomas with Histone H3 K27M Mutation
    Aboian, M. S.
    Solomon, D. A.
    Felton, E.
    Mabray, M. C.
    Villanueva-Meyer, J. E.
    Mueller, S.
    Cha, S.
    AMERICAN JOURNAL OF NEURORADIOLOGY, 2017, 38 (04) : 795 - 800
  • [4] HISTONE H3 PHOSPHORYLATION IN H3K27M MIDLINE GLIOMAS
    Zhang, Liang
    Day, Charles
    Hinchcliffe, Edward
    Daniels, David
    NEURO-ONCOLOGY, 2020, 22 : 302 - 302
  • [5] Diffuse midline gliomas with H3F3B K27I mutation: not all H3 K27M-negative gliomas are histone H3 wildtype
    Lee, Julieann
    Cadwell, Cathryn
    Sloan, Emily
    Hwang, Dick
    Phillips, Joanna
    Pekmezci, Melike
    Bollen, Andrew
    Tihan, Tarik
    Perry, Arie
    Solomon, David
    JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2020, 79 (06): : 672 - 672
  • [6] TREATING HYDROCEPHALUS IN DIFFUSE MIDLINE GLIOMAS WITH AN H3 K27M MUTATION
    Coombs, L.
    LaRocca, R.
    Hata, Jessica
    Nickols, H.
    Spalding, A.
    Mutchnick, Ian
    Moriarity, Thomas
    Gump, William
    Sun, D.
    NEURO-ONCOLOGY, 2020, 22 : 209 - 209
  • [7] H3 K27M and EZHIP Impede H3K27-Methylation Spreading by Inhibiting Allosterically Stimulated PRC2
    Jain, Siddhant U.
    Rashoff, Andrew Q.
    Krabbenhoft, Samuel D.
    Hoelper, Dominik
    Do, Truman J.
    Gibson, Tyler J.
    Lundgren, Stefan M.
    Bondra, Eliana R.
    Deshmukh, Shriya
    Harutyunyan, Ashot S.
    Juretic, Nikoleta
    Jabado, Nada
    Harrison, Melissa M.
    Lewis, Peter W.
    MOLECULAR CELL, 2020, 80 (04) : 726 - +
  • [8] Diffuse Midline Gliomas with Histone H3-K27M Mutation: A Series of 47 Cases Assessing the Spectrum of Morphologic Variation and Associated Genetic Alterations
    Solomon, David A.
    Wood, Matthew D.
    Tihan, Tarik
    Bollen, Andrew W.
    Gupta, Nalin
    Phillips, Joanna J. J.
    Perry, Arie
    BRAIN PATHOLOGY, 2016, 26 (05) : 569 - 580
  • [9] The K27M Mutation in Histone H3 Is Present in Supratentorial Midline Diffuse Gliomas in Young Adult Patients
    Munoz, David
    Ryall, Scott
    Das, Sunit
    Hawkins, Cynthia
    NEUROLOGY, 2016, 86
  • [10] A case series of diffuse midline gliomas harboring H3 K27M mutation
    Barona Garcia, L.
    Ferri Niguez, B.
    Torroba Caron, M. A.
    Lopez Motos, D.
    Ribalta Farres, T.
    Salazar Nicolas, A.
    Oviedo Ramirez, M. I.
    Ortuno Moreno, M. I.
    Caballero Illanes, A.
    Martinez Barba, E.
    VIRCHOWS ARCHIV, 2019, 475 : S379 - S379