In vitro antimicrobial and antimycobacterial activity of some chalcones and their derivatives

被引：0
作者：
Divyesh Patel
Premlata Kumari
Navin B. Patel
机构：
[1] S.V. National Institute of Technology,Department of Applied Chemistry
[2] V.N. South Gujarat University,Department of Chemistry
来源：
Medicinal Chemistry Research | 2013年 / 22卷
关键词：
Coumarin; Chalcone and their derivatives; Antimicrobial activity; Antimycobacterial activity; Structure activity relationship;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In this study, novel series of chalcone derivatives, namely, 4-[4-(3-phenyl-acryloyl)-phenylamino]-chromen-2-one (5a–k) have been synthesized from the intermediate 4-(4-acetyl-phenylamino)-chromen-2-one (4). Cyclization reaction of chalcone (5a–k) with hydrazine hydrate, guanidine nitrate, and malononitrile gives the corresponding 4-[4-(1-acetyl-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)-phenylamino]-chromen-2-one (6a–k), 4-[4-(2-amino-6-phenyl-pyrimidin-4-yl)-phenylamino]-chromen-2-one (7a–k), and 2-amino-6-[4-(2-oxo-2H-chromen-4-ylamino)-phenyl]-4-phenyl-nicotinonitrile (8a–k) derivatives were synthesized. The newly synthesized compounds were evaluated for their antimycobacterial activity and antimicrobial activity against eight bacteria (S.aureus, B. cereus, E. coli, P. aeruginosa, K. pneumoniae, S. typhi, P. vulgaris, and S. flexneri) and four fungi (A. niger, C. albicans, A. fumigatus, and A. clavatus).
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页码：726 / 744
页数：18
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