Vitamin D status among long-term survivors of hematopoietic cell transplantation

被引：0
作者：
K Robien
L G Strayer
N Majhail
D Lazovich
K S Baker
A R Smith
D A Mulrooney
L J Burns
机构：
[1] University of Minnesota School of Public Health,Division of Epidemiology and Community Health
[2] Hematology Oncology Transplant Program,Division of Clinical Research
[3] Blood and Marrow Transplantation Program,Department of Pediatrics
[4] University of Minnesota School of Medicine,undefined
[5] Pediatric Hematology/Oncology,undefined
[6] Blood and Marrow Transplantation Program,undefined
[7] University of Minnesota School of Medicine,undefined
[8] Cancer Outcomes and Survivorship Research Program,undefined
[9] Masonic Cancer Center,undefined
[10] University of Minnesota,undefined
[11] Prevention and Etiology Program,undefined
[12] ,undefined
[13] Masonic Cancer Center,undefined
[14] University of Minnesota,undefined
[15] Transplant Biology and Therapy Research Program,undefined
[16] Masonic Cancer Center,undefined
[17] University of Minnesota,undefined
[18] Fred Hutchinson Cancer Research Center,undefined
[19] University of Washington,undefined
来源：
Bone Marrow Transplantation | 2011年 / 46卷
关键词：
hematopoietic cell transplantation; vitamin D; serum 25(OH)D; cancer survivors; diet; dietary supplements;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Little is known about serum vitamin D levels following hematopoietic cell transplantation (HCT). Patients are instructed to avoid sun exposure because of an increased risk of skin cancers. Altered gastrointestinal absorptive capacity as a result of GVHD, bile acid or pancreatic enzyme insufficiency or bacterial overgrowth may lead to difficulty in absorbing the fat-soluble vitamin D. This study was undertaken to determine the prevalence of serum 25-hydroxyvitamin D (25(OH)D) deficiency, and factors associated with 25(OH)D deficiency, among children and adults who were at least 1 year following HCT. A total of 95 participants (54 males and 41 females) completed a questionnaire on usual diet and lifestyle, and provided a blood sample for 25(OH)D determinations between November 2008 and July 2009. The majority of participants had serum 25(OH)D levels ⩾75 nmol/L (n=62, 65%), 23 had insufficient levels (50–75 nmol/L) and 10 participants were deficient (<50 nmol/L). The majority of participants reported regular use of vitamin D supplements (n=58, 61%). Prednisone use was significantly inversely associated with serum 25(OH)D concentrations. Total vitamin D intake was the strongest single predictor of 25(OH)D concentrations. These findings suggest that 400–600 IU vitamin D per day appears to be required to achieve optimal serum 25(OH)D concentrations following HCT.
引用
收藏
页码：1472 / 1479
页数：7
相关论文
共 122 条
[1]  
Giovannucci E(2006)Prospective study of predictors of vitamin D status and cancer incidence and mortality in men J Natl Cancer Inst 98 451-459
[2]  
Liu Y(2006)Epidemic influenza and vitamin D Epidemiol Infect 134 1129-1140
[3]  
Rimm EB(2007)The anti-inflammatory activity of 1,25-dihydroxyvitamin D3 in macrophages J Steroid Biochem Mol Biol 103 558-562
[4]  
Hollis BW(2005)Association between serum concentrations of 25-hydroxyvitamin D and gingival inflammation Am J Clin Nutr 82 575-580
[5]  
Fuchs CS(2010)Immunomodulatory effects of vitamin D: implications for GVHD Bone Marrow Transplant 45 1463-1468
[6]  
Stampfer MJ(2007)Season of diagnosis is a predictor of cancer survival. Sun-induced vitamin D may be involved: a possible role of sun-induced Vitamin D J Steroid Biochem Mol Biol 103 675-678
[7]  
Cannell JJ(2007)Circulating 25-hydroxyvitamin D levels predict survival in early-stage non-small-cell lung cancer patients J Clin Oncol 25 479-485
[8]  
Vieth R(1997)Reversible muscle weakness in patients with vitamin D deficiency West J Med 167 435-439
[9]  
Umhau JC(2005)Recent developments in vitamin D deficiency and muscle weakness among elderly people Bmj 330 524-526
[10]  
Holick MF(2004)Hypovitaminosis D-induced pain Nutr Rev 62 354-359
12345678910