Poly(I:C) induce bone marrow precursor cells into myeloid-derived suppressor cells

被引：0
作者：
Cong Liu
Chaoxiong Zhang
Hongjuan Lu
Jianming Cai
Zhigang Wang
Jie Chen
Fang Liu
Zhumei Wu
Xiaogang Liu
Weimin Sun
机构：
[1] Second Military Medical University,National Key Laboratory of Medical Immunology & Institute of Immunology
[2] Second Military Medical University,Department of Radiation Medicine
[3] Department of Centre for Disease Prevention and Control,Department of Pediatric Surgery
[4] Chengdu Military Region,Department Gynaecology and Obstetrics
[5] West China Hospital of Sichuan University,Department of Immunology
[6] Yuxi People Hospital,undefined
[7] Second Military Medical University,undefined
来源：
Molecular and Cellular Biochemistry | 2011年 / 358卷
关键词：
Dendritic cells; Myeloid-derived suppressor cells; Poly(I:C) vesicular stomatitis virus;
D O I：
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中图分类号：
学科分类号：
摘要：
Dendritic cells (DC) and myeloid-derived suppressor cells (MDSC) are important cells involved in immune response. DC can be generated from mouse bone marrow (BM) in the presence of granulocyte-macrophage colony-stimulating factor (GM-CSF) and IL-4. Recent studies have revealed that combined treatment of bone marrow MDSC with LPS plus IFN-γ inhibited the DC development but enhanced MDSC functions, such as NO release and T cell suppression. In our study, bone marrow precursor cells cultures in GM-CSF and IL-4 were treated with poly(I:C) through the culture, Gr1+CD11b+ cells with MDSC functions, such as NO release and T cell suppression were accumulated in the culture system. Then the similar phenomenon was observed in the vesicular stomatitis virus infection in vivo. In conclusion, we demonstrated that the bone marrow precursor cells in the presence of GM-CSF and IL-4 can differentiate into MDSC, which is dependent on the dynamic of interaction with poly(I:C).
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页码：317 / 323
页数：6
相关论文
共 213 条
[1]  
Gabrilovich DI(2009)Myeloid-derived suppressor cells as regulators of the immune system Nat Rev Immunol 9 162-174
[2]  
Nagaraj S(1991)The dendritic cell system and its role in immunogenicity Annu Rev Immunol 9 271-296
[3]  
Steinman RM(2007)Taking dendritic cells into medicine Nature 449 419-426
[4]  
Steinman RM(1998)Dendritic cells and the control of immunity Nature 392 245-252
[5]  
Banchereau J(2002)Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance Proc Natl Acad Sci USA 99 351-358
[6]  
Banchereau J(2010)Th17 and regulatory T cells in mediating and restraining inflammation Cell 140 845-858
[7]  
Steinman RM(2004)Splenic stroma drives mature dendritic cells to differentiate into regulatory dendritic cells Nat Immunol 5 1124-1133
[8]  
Steinman RM(2009)Tumor-educated CD11bhighIalow regulatory dendritic cells suppress T cell response through arginase I J Immunol 182 6207-6216
[9]  
Nussenzweig MC(2005)Regulation of immune responses by Nat Rev Immunol 5 641-654
[10]  
Littman DR(2008)-arginine metabolism Immunol Rev 222 180-191
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