Nonphosphorylatable PEA15 mutant inhibits epithelial-mesenchymal transition in triple-negative breast cancer partly through the regulation of IL-8 expression

被引：0
作者：
Jihyun Park
Moises J. Tacam
Gaurav Chauhan
Evan N. Cohen
Maria Gagliardi
Lakesla R. Iles
Naoto T. Ueno
Venkata L. Battula
Yoo-Kyoung Sohn
Xiaoping Wang
Hak-Sung Kim
Savitri Krishnamurthy
Natalie W. Fowlkes
Morgan M. Green
Geoffrey A. Bartholomeusz
Debu Tripathy
James M. Reuben
Chandra Bartholomeusz
机构：
[1] The University of Texas MD Anderson Cancer Center,Section of Translational Breast Cancer Research, Department of Breast Medical Oncology
[2] The University of Texas MD Anderson Cancer Center,Department of Hematopathology
[3] The University of Texas MD Anderson Cancer Center,Department of Leukemia
[4] The University of Texas MD Anderson Cancer Center,Department of Experimental Therapeutics
[5] Korea Advanced Institute of Science and Technology,Department of Biological Sciences
[6] The University of Texas MD Anderson Cancer Center,Department of Pathology
[7] The University of Texas MD Anderson Cancer Center,Department of Veterinary Medicine & Surgery
[8] The University of Texas MD Anderson Cancer Center,Department of Breast Medical Oncology
来源：
Breast Cancer Research and Treatment | 2021年 / 189卷
关键词：
PEA15; EMT; Triple-negative breast cancer; IL-8; Ets-1;
D O I：
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中图分类号：
学科分类号：
摘要：
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页码：333 / 345
页数：12
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[1]  
DeSantis CE(2017)Breast cancer statistics, 2017, racial disparity in mortality by state CA Cancer J Clin 67 439-448
[2]  
Ma J(2015)Targeted therapies for triple-negative breast cancer: combating a stubborn disease Trends Pharmacol Sci 36 822-846
[3]  
Goding Sauer A(2018)Triple negative breast cancer: emerging therapeutic modalities and novel combination therapies Cancer Treat Rev 62 110-122
[4]  
Newman LA(2019)Insights into molecular classifications of triple-negative breast cancer: improving patient selection for treatment Cancer Discov 9 176-198
[5]  
Jemal A(2010)PEA-15 inhibits tumorigenesis in an MDA-MB-468 triple-negative breast cancer xenograft model through increased cytoplasmic localization of activated extracellular signal-regulated kinase Clin Cancer Res 16 1802-1811
[6]  
Kalimutho M(2007)PEA-15 inhibits tumor cell invasion by binding to extracellular signal-regulated kinase 1/2 Cancer Res 67 1536-1544
[7]  
Parsons K(2015)PEA-15 facilitates EGFR dephosphorylation via ERK sequestration at increased ER-PM contacts in TNBC cells FEBS Lett 589 1033-1039
[8]  
Mittal D(2001)PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase Dev Cell 1 239-250
[9]  
Lopez JA(1998)The death effector domain of PEA-15 is involved in its regulation of integrin activation J Biol Chem 273 33897-33900
[10]  
Srihari S(2000)Death effector domain protein PEA-15 potentiates Ras activation of extracellular signal receptor-activated kinase by an adhesion-in`ent mechanism Mol Biol Cell 11 2863-2872
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