Follicular helper T-cell lymphomas: disease spectrum, relationship with clonal hematopoiesis, and mimics. A report of the 2022 EA4HP/SH lymphoma workshop

被引：0
作者：
Sarah L Ondrejka
Catalina Amador
Fina Climent
Siok-Bian Ng
Lorinda Soma
Alberto Zamo
Stefan Dirnhofer
Leticia Quintanilla-Martinez
Andrew Wotherspoon
Lorenzo Leoncini
Laurence de Leval
机构：
[1] Cleveland Clinic,Pathology and Laboratory Medicine Institute
[2] University of Miami,Division of Hematopathology, Department of Pathology and Laboratory Medicine
[3] Hospital Universitari de Bellvitge,Pathology Department
[4] IDIBELL,Department of Pathology, Yong Loo Lin School of Medicine
[5] L’Hospitalet De Llobregat,Department of Pathology
[6] National University of Singapore,Institute of Pathology
[7] City of Hope National Medical Center,Institute of Medical Genetics and Pathology
[8] University of Würzburg,Institute of Pathology and Neuropathology, Eberhard Karls University of Tübingen and Comprehensive Cancer Center
[9] University Hospital Basel,Department of Histopathology
[10] University of Basel,Department of Medical Biotechnology
[11] University Hospital Tübingen,Institute of Pathology, Department of Laboratory Medicine and Pathology
[12] The Royal Marsden Hospital,undefined
[13] University of Siena,undefined
[14] Lausanne University Hospital and Lausanne University,undefined
来源：
Virchows Archiv | 2023年 / 483卷
关键词：
T-cell lymphoma; TFH lymphoma; Angioimmunoblastic T-cell lymphoma; Peripheral T-cell lymphoma; Clonal hematopoiesis; High-throughput sequencing; EA4HP workshop;
D O I：
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摘要：
Follicular helper T-cell lymphomas (TFH lymphomas) were discussed in session V of the lymphoma workshop of the European Association for Haematopathology (EA4HP)/Society for Hematopathology (SH) 2022 meeting in Florence, Italy. The session focused on the morphologic spectrum of TFH lymphoma, including its three subtypes: angioimmunoblastic-type (AITL), follicular-type, and not otherwise specified (NOS). The submitted cases encompassed classic examples of TFH lymphoma and unusual cases such as those with early or indolent presentations, associated B-cell proliferations, or Hodgkin/Reed–Sternberg-like cells. The relationship between TFH lymphoma and clonal hematopoiesis was highlighted by several cases documenting divergent evolution of myeloid neoplasm and AITL from shared clonal mutations. The distinction between TFH lymphoma and peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS), was stressed, and many challenging examples were presented. Various cases highlighted the difficulties of differentiating TFH lymphoma from other established types of lymphoma and reactive conditions. Cutaneous T-cell lymphoma expressing TFH markers, particularly when resulting in lymph node involvement, should be distinguished from TFH lymphomas. Additional immunophenotyping and next-generation sequencing studies were performed on various cases in this session, highlighting the importance of these technologies to our current understanding and classification of TFH lymphomas.
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页码：349 / 365
页数：16
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