Patterns of care and survival for adolescents and young adults with acute leukaemia – a population-based study

被引:0
作者
C A Stiller
S Benjamin
R A Cartwright
J V Clough
D W Gorst
M E Kroll
J R Y Ross
K Wheatley
J A Whittaker
PRA Taylor
S J Proctor
机构
[1] Childhood Cancer Research Group,
[2] University of Oxford,undefined
[3] Leukaemia Research Fund Centre for Clinical Epidemiology,undefined
[4] University of Leeds,undefined
[5] Countess of Chester Hospital,undefined
[6] Royal Lancaster Infirmary,undefined
[7] Northampton General Hospital,undefined
[8] Cliftonville,undefined
[9] Clinical Trial Service Unit,undefined
[10] Radcliffe Infirmary,undefined
[11] University of Wales College of Medicine,undefined
[12] Heath Park,undefined
[13] Royal Victoria Infirmary,undefined
来源
British Journal of Cancer | 1999年 / 79卷
关键词
acute leukaemia; survival rates; place of treatment; clinical trials;
D O I
暂无
中图分类号
学科分类号
摘要
We report a population-based study of patterns of care and survival for people with acute leukaemia diagnosed at age 15–29 years during 1984–94 in regions of England and Wales covered by specialist leukaemia registries. There were 879 patients: 417 with acute lymphoblastic leukaemia (ALL) and 462 with acute myeloid leukaemia (AML). For ALL, actuarial survival rates were 43% at 5 years after diagnosis and 37% at 10 years. Survival improved significantly between 1984–88 and 1989–94 for those aged 15–19 at diagnosis. Patients entered in national clinical trials and those not entered had similar survival rates. Survival rates were similar at teaching and non-teaching hospitals and at hospitals treating different numbers of study patients per year. For AML, survival rates were 42% at 5 years after diagnosis and 39% at 10 years. Survival improved significantly between 1984–88 and 1989–94. Patients entered in the Medical Research Council AML10 trial had a higher survival rate than those who were in the earlier AML9 trial. Survival did not vary with category of hospital. We conclude that survival has improved for adolescents and young adults with acute leukaemia but that there is at present no evidence that centralized treatment results in a survival benefit for patients in this age group.
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页码:658 / 665
页数:7
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