Causes of oxidative stress in Alzheimer disease

被引：0

作者：

X. Zhu

B. Su

X. Wang

M. A. Smith

G. Perry

机构：

[1] Case Western Reserve University,Department of Pathology

[2] University of Texas at San Antonio,College of Sciences

来源：

Cellular and Molecular Life Sciences | 2007年 / 64卷

关键词：

Alzheimer disease; amyloid-β; antioxidant; iron; metals; mitochondria; oxidative stress; pathogenesis; phosphorylation; reactive oxygen species; tau;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Oxidative stress is one of the earliest events of Alzheimer disease (AD), with implications as an important mediator in the onset, progression and pathogenesis of the disease. The generation of reactive oxygen species (ROS) and its consequent cellular damage/response contributes to much of the hallmark AD pathology seen in susceptible neurons. The sources of ROS-mediated damage appear to be multi-faceted in AD, with interactions between abnormal mitochondria, redox transition metals, and other factors. In this review, we provide an overview of these potential causes of oxidative stress in AD.

引用

页码：2202 / 2210

页数：8