Intra-sellar salivary gland-like pleomorphic adenoma arising within the wall of a Rathke's cleft cyst

被引:23
作者
Chimelli L. [1 ]
Gadelha M.R. [1 ]
Une K. [1 ]
Carlos S. [2 ]
Pereira P.J.M. [2 ]
Santos J.L. [3 ]
Niemeyer Filho P. [2 ]
Duarte F. [1 ]
机构
[1] Departments of Pathology and Endocrinology, University Hospital, Federal University of Rio de Janeiro
[2] Department of Neurosurgery, Santa Casa de Miseriçrdia do Rio de Janeiro
[3] Department of Pathology, Santa Casa de Miseriçrdia do Rio de Janeiro
关键词
Pleomorphic adenoma; Rathke's cleft cyst; Salivary gland; Sella turcica;
D O I
10.1023/A:1012888315577
中图分类号
学科分类号
摘要
Salivary gland rests occur in the posterior lobe of the pituitary gland near or often communicating with the Rathke's cleft or its cystic subdivisions, and are usually incidental autopsy findings. They are attributed to the oropharyngeal development of the Rathke's pouch and may rarely give rise to salivary gland-like tumors in the sella. We present a pleomorphic adenoma, a rare tumor of the sellar region, that has not been previously recognized in association with Rathke's cleft cyst. It occurred in a 44-year-old man who presented with hypopituitarism and reduced vision. Magnetic resonance imaging showed a sellar mass with suprasellar extension which was totally removed. It consisted of segments of a cyst wall lined by focally ciliated columnar of cuboid epithelium containing goblet cells. An eosinophilic granular material with cholesterol clefts represented the contents of the cyst. Within its wall there was a tumor with ductal structures and non-ductal varied cellular components including hypercellular areas of spindle and ovoid cells forming interlacing fascicles. Individual cells appeared to float in abundant mucinous material. The appearances were those of a salivary gland pleomorphic adenoma arising within the wall of a Rathke's cleft cyst. The myoepithelial nature of non-ductal tumor cells was confirmed with immunocytochemistry. The existence of seromucous glands communicating with the Rathke's cleft remnants, explains the concomitant occurrence of the tumor and the cyst. The rare neoplasm from salivary gland rest should be considered in the differential diagnosis of unusual sellar and suprasellar tumors.
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页码:257 / 261
页数:4
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  • [1] McKeever P.E., Blaivas M., Sima A.A.F., Neoplasms of the sellar region, Surgical Pathology of the Pituitary Gland in the Series Major Problems in Pathology, 27, pp. 141-211, (1993)
  • [2] Asa S.L., Tumors of the pituitary gland, Atlas of Tumor Pathology, (1998)
  • [3] Schochet S.S., McCormick W.F., Halmi N.S., Salivary gland rests in the human pituitary: Light and electron microscopical study, Arch Pathol, 98, pp. 193-200, (1974)
  • [4] Hampton T.A., Scheithauer B.W., Rojiani A.M., Kovacs K., Horvath E., Vogt P., Salivary gland-like tumors of the sellar region, Am J Surg Pathol, 21, pp. 424-434, (1997)
  • [5] Scheithauer B.W., Pathology of the pituitary and sellar region: Exclusive of pituitary adenoma, Pathology Annual 1985, pp. 67-155, (1985)
  • [6] Kato T., Aida T., Abe H., Miyamachi K., Hida K., Taneda M., Ogata A., Ectopic salivary gland within the pituitary gland. Case report, Neurol Med Chir, 28, pp. 930-933, (1988)
  • [7] Schaetti P., Argentino Storino A., Heinrichs M., Mirea D., Popp A., Karbe E., Aberrant craniopharyngeal structures within the neurohypophysis of rats, Exp Toxicol Pathol, 47, pp. 129-137, (1995)
  • [8] Tatter S.B., Edgar M.A., Klibanski A., Swearingen B., Symptomatic salivary-rest cyst of the sella turcica, Acta Neurochir (Wien), 135, pp. 150-153, (1995)
  • [9] Yamakita N., Ikeda T., Murai T., Kimura M., Komaki T., Miura K., Iwamura M., Hirata T., Umezaki A., Panhypopituitarism due to Rathke's cleft cyst associated with pituitary oncocytoma, Intern Med, 36, pp. 107-112, (1997)
  • [10] Gilcrease M.Z., Delgado R., Albores Saavedra J., Intrasellar adenoid cystic carcinoma and papillary mucinous adenocarcinoma: Two previously undescribed primary neoplasms at this site, Ann Diagn Pathol, 3, pp. 141-147, (1993)