Association of the SOD2 Ala(–9)Val and SOD3 Arg213Gly Polymorphisms with Diabetic Polyneuropathy in Diabetes Mellitus Type 1

被引：0
作者：
E. V. Zotova
D. A. Chistyakov
E. V. Savost'yanov
T. R. Bursa
I. V. Galeev
I. A. Strokov
V. V. Nosikov
机构：
[1] State Research Center GosNIIgenetika,Department of Endocrinology and Diabetology
[2] Russian Medical Academy of Postgraduate Education,undefined
[3] WHO Center of Informatics in Diabetes,undefined
来源：
Molecular Biology | 2003年 / 37卷
关键词：
diabetes mellitus type 1; diabetic polyneuropathy; oxidative stress; superoxide dismutase; polymerase chain reaction; human;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Single-nucleotide polymorphisms of the genes for mitochondrial (SOD2) and extracellular (SOD3) superoxide dismutases were tested for association with diabetic polyneuropathy (DPN) in diabetes mellitus (DM) type 1. Patients (N = 180) were divided into two groups with nonoverlapping (polar) phenotypes. Group DPN+ included 86 individuals with DPN and DM type 1 record of no more than 5 years. Group DPN– included 94 patients with DM type 1 record of more than 10 years but without clinical signs of DPN. Fisher's exact test revealed significant differences in allele and genotype frequencies for the two groups. Higher frequencies of SOD2 allele Val and genotype Val/Val and of SOD3 allele Arg and genotype Arg/Arg were established for group DPN+. On this evidence, SOD2 and SOD3 were associated with DPN in DM type 1.
引用
收藏
页码：345 / 348
页数：3
相关论文
共 96 条
  • [1] De Los Rios M.G.(1999)Pathophysiology of diabetic nephropathy Diabetografiya 13 2-5
  • [2] Durruty P.(1999)Pathophysiological mechanisms of vascular complications in diabetes mellitus-role of oxidative stress Medikografiya 21 25-28
  • [3] Ceriello A.(1994)Formation and structure of crosslinking and monomeric pyrrole autooxidation products in 2,5-hex-anedione-treated amino acids, peptides, and protein Chem. Res. Toxical. 7 551-558
  • [4] Zhu M.(1997)Metabolic and vascu-lar factors in the pathogenesis of diabetic neuropathy Diabetes 46 31-37
  • [5] Spink D.C.(1992)Peroxidative changes in experimental diabetes mellitus Indian J. Med. Res. 96 176-181
  • [6] Yan B.(1995)The role of oxidative stress in neuropathy and other diabetic complications Diabetes metabolism reviews. 11 181-192
  • [7] Bank S.(1999)Nerve conduction and antioxidant levels in experimentally diabetic rats: effects of streptozotocin dose and diabetes duration Metabolism. 48 442-447
  • [8] DeCaprio A.P.(1998)Experimental diabetic neuropathy: role of oxidative stress and mechanisms involved Bio-factors. 8 41-43
  • [9] Cameron N.E.(1990)Analysis of extracellular superox-ide dismutase in tissue homogenates and extracellular fluids Methods Enzymol. 186 260-265
  • [10] Cotter M.A.(1996)Structural dimorphism in the mitochondrial argeting sequence in the human manganese superoxide dismutase gene Biochem. Biophys. Res. Commun. 226 561-565
12345678910