Annular leukocytoclastic vasculitis associated with anti-tuberculosis medications: A case report

被引:11
作者
Chanprapaph K. [1 ]
Roongpisuthipong W. [2 ]
Thadanipon K. [1 ]
机构
[1] Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok
[2] Department of Medicine, Vajira Hospital, University of Bangkok Metropolis, Bangkok
关键词
Amlodipine; Ofloxacin; Glipizide; Leukocytoclastic Vasculitis; Chlorzoxazone;
D O I
10.1186/1752-1947-7-34
中图分类号
学科分类号
摘要
Introduction. Anti-tuberculosis drug-induced cutaneous leukocytoclastic vasculitis has been rarely reported. To the best of our knowledge, this is the first reported case of annular leukocytoclastic vasculitis associated with anti-tuberculosis drug administration. Case presentation. We report a case of annular leukocytoclastic vasculitis induced by anti-tuberculosis medication. A 62-year-old Thai man presented to our facility with a generalized exanthematous rash on his trunk and extremities that resolved shortly afterwards. Subsequently, he developed multiple, erythematous-to-purplish, non-blanchable macules and papules with an annular arrangement on his extremities. The skin rash occurred after two weeks of anti-tuberculosis medication. The histopathology of the purpuric skin lesion was consistent with leukocytoclastic vasculitis. The skin lesion improved after discontinuation of the anti-tuberculosis drugs and treatment with oral antihistamine and topical corticosteroid drugs. Streptomycin, ethambutol and ofloxacin were administered as second-line anti-tuberculosis therapy during his hospitalization. No adverse reactions were observed. Conclusions: Leukocytoclastic vasculitis should be considered in the differential diagnosis of annular non-blanchable macules and papules. Although rare, anti-tuberculosis drugs should be considered potential causes of drug-induced annular leukocytoclastic vasculitis. © 2013 Chanprapaph et al.; licensee BioMed Central Ltd.
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  • [1] Imanishi H., Tsuruta D., Ishii M., Kobayashi H., Annular leucocytoclastic vasculitis, Clin Exp Dermatol, 34, (2009)
  • [2] Nousari H.C., Kimyai-Asadi A., Stone J.H., Annular leukocytoclastic vasculitis associated with monoclonal gammopathy of unknown significance, J Am Acad Dermatol, 43, pp. 955-957, (2000)
  • [3] Khasnis A., Langford C.A., Update on vasculitis, J Allergy Clin Immunol, 123, pp. 1226-1236, (2009)
  • [4] Tan W.C., Ong C.K., Kang S.C., Razak M.A., Two years review of cutaneous adverse drug reaction from first line anti-tuberculosis drugs, Med J Malaysia, 62, pp. 143-146, (2007)
  • [5] Kim J.H., Moon J.I., Kim J.E., Choi G.S., Park H.S., Ye Y.M., Yim H., Cutaneous leukocytoclastic vasculitis due to anti-tuberculosis medications, rifampin and pyrazinamide, Allergy Asthma Immunol Res, 2, pp. 55-58, (2010)
  • [6] Cribier B., Cunny J.F., Schubert B., Colson A., Truchetet F., Grosshans E., Recurrent annular erythema with purpura: A new variant of leucocytoclastic vasculitis responsive to dapsone, Br J Dermatol, 135, pp. 972-975, (1996)
  • [7] Kelly R.I., Cook M.G., Marsden R.A., Annular vasculitis associated with pregnancy, Br J Dermatol, 129, pp. 599-601, (1993)
  • [8] Chiu C.S., Chang Y.C., Chung W.H., Yang L.J., Ho H.C., Chen M.J., Hong H.S., Annular leucocytoclastic vasculitis induced by chlorzoxazone, Br J Dermatol, 150, (2004)
  • [9] Najarian D.J., Packianathan V., Zeitouni N.C., Annular leukocytoclastic vasculitis associated with sorafenib administration, J Drugs Dermatol, 9, pp. 697-698, (2010)
  • [10] Meissner M., Kaufmann R., Annular leukocytoclastic vasculitis after the administration of an amlodipine generic, J Eur Acad Dermatol Venereol, 23, pp. 238-239, (2009)