Dietary diosgenin transcriptionally down-regulated intestinal NPC1L1 expression to prevent cholesterol gallstone formation in mice

被引：0
作者：
Weiyi Shen
Wentao Shao
Qihan Wang
Bo Wang
Gang Zhao
Aihua Gu
Zhaoyan Jiang
Hai Hu
机构：
[1] School of Medicine,Center of Gallstone Disease, Shanghai East Hospital, and Institution of Gallstone Disease
[2] Tongji University,State Key Laboratory of Reproductive Medicine, School of Public Health
[3] Nanjing Medical University,Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Center for Global Health
[4] Nanjing Medical University,undefined
来源：
Journal of Biomedical Science | / 30卷
关键词：
Gallstone; Diosgenin; Cholesterol; NPC1L1; Microbiome;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Diosgenin prevented cholesterol gallstone formation.Diosgenin could directed inhibited of STAT3 mediated transcription of Npc1l1 gene.Diosgenin could also modulate gut microbiota-LPS mediated STAT3 activation.Diosgenin inhibited intestinal cholesterol absorption, thereby, lowered cholesterol in liver and bile.
引用
收藏
相关论文
共 191 条
[1]  
Polychronidis G(2016)EASL clinical practice guidelines on the prevention, diagnosis and treatment of gallstones J Hepatol 65 146-181
[2]  
Wang K(2021)Gallstone disease and risk of conventional adenomas and serrated polyps: a prospective study Cancer Epidemiol Biomarkers Prev 30 2346-2349
[3]  
Lo CH(2020)Prevalence of gallstone in Mainland China: a meta-analysis of cross-sectional studies Clin Res Hepatol Gastroenterol 44 e69-e71
[4]  
Wang L(2016)Gallstones Nat Rev Dis Primers 2 16024-505
[5]  
He M(2019)Gallbladder bile supersaturated with cholesterol in gallstone patients preferentially develops from shortage of bile acids J Lipid Res 60 498-863
[6]  
Knudsen MD(2018)Fast morphological gallbladder changes triggered by a hypercholesterolemic diet Ann Hepatol 17 857-429
[7]  
Su Z(2020)Cryo-EM structures of NPC1L1 reveal mechanisms of cholesterol transport and ezetimibe inhibition Sci Adv 6 421-11837
[8]  
Gong Y(2017)Effect of inhibition of intestinal cholesterol absorption on the prevention of cholesterol gallstone formation Med Chem 13 11829-4030
[9]  
Liang Z(2021)Recent advances, novel targets and treatments for cholelithiasis; a narrative review Eur J Pharmacol 908 1304-1133
[10]  
Lammert F(2021)Dietary plant sterols prevented cholesterol gallstone formation in mice Food Funct 12 4015-509
12345678910