Antifibrotic and Anti-Inflammatory Activity of a Neuroleptic Drug on the Model of Pulmonary Fibrosis

被引：0
|
作者：
A. M. Dygai
E. G. Skurikhin
T. V. Andreeva
O. V. Pershina
L. A. Ermolaeva
E. S. Khmelevskaya
V. A. Krupin
A. M. Reztsova
I. E. Stepanova
机构：
[1] Siberian Division of the Russian Academy of Medical Sciences,Institute of Pharmacology
来源：
Bulletin of Experimental Biology and Medicine | 2012年 / 152卷
关键词：
bleomycin; pulmonary fibrosis; neuroleptic drug; stem cells; committed hemopoietic and mesenchymal precursors;
D O I：
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学科分类号：
摘要：
The effect of course treatment with neuroleptic haloperidol on the inflammatory response and state of the connective tissue in the lungs of C57Bl/6 mice was studied on the model of toxic pulmonary fibrosis induced by intratracheal administration of bleomycin. This neuroleptic decreased the inflammatory response and reduced the growth of the connective tissue in the lungs. The anti-infl ammatory effect of haloperidol is related to a decrease in activity of bone marrow hemopoietic stem cells and committed hemopoietic precursors. The antifibrotic effect of this drug is associated with inhibition of mesenchymal precursor cells.
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页码：679 / 683
页数：4
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