A serological survey for antibodies against foot-and-mouth disease virus (FMDV) in domestic pigs during outbreaks in Kenya

被引：0
作者：
Sabenzia N. Wekesa
Alice Namatovu
Abraham K. Sangula
Moses T. Dhikusooka
Vincent B. Muwanika
Kirsten Tjørnehøj
机构：
[1] Foot-and-Mouth Disease Laboratory,Department of Environmental Management, College of Agricultural and Environmental Sciences
[2] Makerere University,Department of Biotechnical and Diagnostic Sciences, College of Veterinary Medicine, Animal Resources and Biosecurity
[3] Makerere University,National Animal Disease Diagnostics and Epidemiology Centre
[4] Ministry of Agriculture Animal Industry and Fisheries,National Veterinary Institute
[5] Technical University of Denmark,undefined
来源：
Tropical Animal Health and Production | 2014年 / 46卷
关键词：
Domestic pigs; Eastern Africa; Endemic areas; Foot-and-mouth disease; SAT 1;
D O I：
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中图分类号：
学科分类号：
摘要：
Foot-and-mouth disease (FMD) is endemic in Kenya and has been well studied in cattle, but not in pigs, yet the role of pigs is recognised in FMD-free areas. This study investigated the presence of antibodies against FMD virus (FMDV) in pigs sampled during a countrywide random survey for FMD in cattle coinciding with SAT 1 FMDV outbreaks in cattle. A total of 191 serum samples were collected from clinically healthy pigs in 17 districts. Forty-two of the 191 sera were from pigs vaccinated against serotypes O/A/SAT 2 FMDV. Antibodies against FMDV non-structural proteins were found in sera from 30 vaccinated and 71 non-vaccinated pigs, altogether 101/191 sera (53 %), and 91 % of these (92/101) also had antibodies measurable by serotype-specific ELISAs, predominantly directed against SAT 1 with titres of 10–320. However, only five high titres against SAT 1 in vaccinated pigs were confirmed by virus neutralisation test (VNT). Due to high degree of agreement between the two ELISAs, it was concluded that positive pigs had been infected with FMDV. Implications of these results for the role of pigs in the epidemiology of FMD in Kenya are discussed, and in-depth studies are recommended.
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页码：575 / 581
页数：6
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