PHF6 mutations in T-cell acute lymphoblastic leukemia

被引：0

作者：

Pieter Van Vlierberghe

Teresa Palomero

Hossein Khiabanian

Joni Van der Meulen

Mireia Castillo

Nadine Van Roy

Barbara De Moerloose

Jan Philippé

Sara González-García

María L Toribio

Tom Taghon

Linda Zuurbier

Barbara Cauwelier

Christine J Harrison

Claire Schwab

Markus Pisecker

Sabine Strehl

Anton W Langerak

Jozef Gecz

Edwin Sonneveld

Rob Pieters

Elisabeth Paietta

Jacob M Rowe

Peter H Wiernik

Yves Benoit

Jean Soulier

Bruce Poppe

Xiaopan Yao

Carlos Cordon-Cardo

Jules Meijerink

Raul Rabadan

Frank Speleman

Adolfo Ferrando

机构：

[1] Institute for Cancer Genetics,Department of Pediatric Oncology/Hematology

[2] Columbia University Medical Center,Department of Pathology

[3] Center for Medical Genetics,Department of Pediatric Hemato

[4] Ghent University Hospital,Oncology

[5] Erasmus MC,Department of Clinical Chemistry

[6] Columbia University Medical Center,Department of Hematology

[7] Center for Computational Biology and Bioinformatics,Department of Immunology

[8] Columbia University,Department of Genetics and Molecular Pathology

[9] Ghent University Hospital,Department of Pediatrics

[10] Immunology and Microbiology,Department of Biostatistics and Computational Biology

[11] Ghent University Hospital,Department of Pediatrics

[12] Centro de Biología Molecular “Severo Ochoa”,undefined

[13] Consejo Superior de Investigaciones Científicas (CSIC),undefined

[14] Universidad Autónoma de Madrid (UAM),undefined

[15] Hospital St-Jan,undefined

[16] Leukaemia Research Cytogenetics Group,undefined

[17] Northern Institute for Cancer Research,undefined

[18] Newcastle University,undefined

[19] Children's Cancer Research Institute,undefined

[20] St. Anna Kinderkrebsforschung,undefined

[21] Erasmus MC,undefined

[22] University of Adelaide,undefined

[23] University of Adelaide,undefined

[24] On behalf of the Dutch Childhood Oncology Group (DCOG),undefined

[25] Montefiore Medical Center North,undefined

[26] Rambam Medical Center and Technion,undefined

[27] Israel Institute of Technology,undefined

[28] Hematology Laboratory APHP,undefined

[29] INSERM U944,undefined

[30] Hôpital Saint Louis,undefined

[31] Dana-Farber Cancer Institute,undefined

[32] Columbia University Medical Center,undefined

来源：

Nature Genetics | 2010年 / 42卷

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摘要：

Adolfo Ferrando and colleagues identify frequent inactivating mutations and deletions in the X chromosome gene PHF6 in T-cell acute lymphoblastic leukemia. PHF6 mutations are found almost exclusively in males and are associated with leukemias driven by aberrant expression of TLX1 and TLX3.

引用

页码：338 / 342

页数：4

共 42 条

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