Attenuation of brain inflammatory response after focal cerebral ischemia/reperfusion with Xuesaitong Injection in rats

被引:4
|
作者
He Wei
Xu Xiao-jun
机构
[1] Gannan Medical College,Department of Pharmacology
[2] Affiliated Hospital of Gannan Medical College,Department of Pharmacy
关键词
Xuesaitong Injection; total saponins of panax notoginseng; cerebral ischemia; brain injury; neutrophil; intercellular adhesion molecule-1;
D O I
10.1007/BF02836523
中图分类号
学科分类号
摘要
Objective: To investigate the neuro-protective effect of Xuesaitong Injection XST on brain inflammatory response after transient focal cerebral ischemia/reperfusion in rats.Methods: Focal cerebral ischemia/reperfusion models of male rats were induced by transient occlusion for 2 h of middle cerebral artery (MCA) which was followed by 24 h reperfusion. XST was administered through intraperitoneal injection of 25 mg/kg or 50 mg/kg at 4 h after the onset of ischemia. After reperfusion for 24 h, the neurological function score was evaluated, the brain edema was detected with dry-wet weight method, the myeloperoxidase (MPO) activity and the expression of intercellular adhesion molecule-1 (ICAM-1) of ischemic cerebral cortex and caudate putamen was determined by spectrophotometry and immunohistochemistry respectively.Results: XST not only lowered neurological function score at the dose of 50 mg/kg, but reduced brain edema and inhibited MPO activity and ICAM-1 expression as compared with the ischemia/reperfusion model group (P < 0.01).Conclusion: XST has a definite effect on inhibiting the expression of ICAM-1 and neutrophil infiltration in rats with cerebral ischemia/reperfusion when treatment started at 4 h after ischemia onset, and also attenuates inflammation in the infarcted cerebral area.
引用
收藏
页码:203 / 206
页数:3
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