Genetic variation study of 12 X chromosomal STR in central Thailand population

被引：0
作者：
Kornkiat Vongpaisarnsin
Achara Boonlert
Kawin Rasmeepaisarn
Piyawan Dangkao
机构：
[1] Chulalongkorn University,Department of Forensic Medicine, Faculty of Medicine
[2] Forensic Serology and DNA,undefined
[3] King Chulalongkorn Memorial Hospital,undefined
来源：
International Journal of Legal Medicine | 2016年 / 130卷
关键词：
X chromosome; Short tandem repeat; Central Thailand; Haplotype; Linkage disequilibrium;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Genetic data from 12 short tandem repeats (STR) on the X chromosome are currently used in forensics studies to resolve issues related to complex kinship or when data is missing or ambiguous. In this study, we genotyped these 12 X chromosome STR in DNA collected from individuals from central Thailand (n = 391, 282 men and 109 women) and used this information to calculate allele and haplotype frequencies as well as forensic parameters for kinship calculations. Polymorphism information contents of the loci were range from 0.5283–0.9247, and powers of discrimination in females and males were 0.7666–0.9905 and 0.6085–0.9291, respectively. A diallelic pattern was observed at the locus DXS7132. Moreover, a comparison of genetic distance revealed a close relationship within Asian countries. Our results indicate that the X chromosomal short tandem repeat (X-STR) multiplex system provides highly informative genetic data and could be advantageous in forensic studies.
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页码：1497 / 1499
页数：2
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