Exploring privileged structures: The combinatorial synthesis of cyclic peptides

被引：0

作者：

Douglas A. Horton

Gregory T. Bourne

Mark L. Smythe

机构：

[1] The University of Queensland,Institute for Molecular Bioscience

[2] The University of Queensland,Protagonist Pty. Ltd., Level 7 Gehrmann Laboratories

来源：

Molecular Diversity | 2000年 / 5卷

关键词：

combinatorial chemistry; cyclic peptide; diketopiperazine; library synthesis; piperazine-2; 5-dione; privileged structure; ring contraction; solid-phase;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Head-to-tail cyclic peptides have been reported to bind to multiple, unrelated classesof receptor with high affinity. They may therefore be considered to beprivileged structures. This review outlines the strategies by which bothmacrocyclic cyclic peptides and cyclic dipeptides or diketopiperazines havebeen synthesised in combinatorial libraries. It also briefly outlines someof the biological applications of these molecules, thereby justifying theirinclusion as privileged structures.

引用

页码：289 / 304

页数：15

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