Current status of imaging pancreatic islets

被引:10
作者
Virostko J. [1 ]
Jansen E.D. [1 ]
Powers A.C. [1 ]
机构
[1] Division of Diabetes, Endocrinology, and Metabolism, Vanderbilt University, Nashville
基金
美国国家卫生研究院;
关键词
Positron Emission Tomography; Pancreatic Islet; Islet Transplantation; Bioluminescence Imaging; Islet Mass;
D O I
10.1007/s11892-006-0069-9
中图分类号
学科分类号
摘要
The ability to image the pancreatic islet in vivo would enhance our understanding of diabetes and accelerate improvements in islet transplantation. However, the small size of islets and their diffuse distribution (both natively and after transplantation) present formidable challenges for current imaging techniques. This article reviews the relative merits and shortcomings of several imaging modalities in humans and in animal models of diabetes. Copyright © 2006 by Current Science Inc.
引用
收藏
页码:328 / 332
页数:4
相关论文
共 42 条
[1]  
Shapiro A.M.J., Lakey J.R.T., Ryan E.A., Et al., Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen, N Engl J Med, 343, pp. 230-238, (2000)
[2]  
Hirshberg B., Rother K.I., Digon I.B., Et al., State of the art: Islet transplantation for the cure of type 1 diabetes mellitus, Rev Endocr Metab Disord, 4, pp. 381-389, (2003)
[3]  
Paty B.W., Bonner-Weir S., Laughlin M.R., Et al., Toward development of imaging modalities for islets after transplantation: Insights from the National Institutes of Health Workshop on Beta Cell Imaging, Transplantation, 77, pp. 1133-1137, (2004)
[4]  
Cassidy P.J., Radda G.K., Molecular imaging perspectives, J R Soc Interface, 2, pp. 133-144, (2005)
[5]  
Markmann J.F., Rosen M., Siegelman E.S., Et al., Magnetic resonance-defined periportal steatosis following intraportal islet transplantation: A functional footprint of islet graft survival?, Diabetes, 52, pp. 1591-1594, (2003)
[6]  
Maffi P., Angeli E., Bertuzzi F., Et al., Minimal focal steatosis of liver after islet transplantation in humans: A long-term study, Cell Transplant, 14, pp. 727-733, (2005)
[7]  
Bhargava R., Senior P.A., Ackerman T.E., Et al., Prevalence of hepatic steatosis after islet transplantation and its relation to graft function, Diabetes, 53, pp. 1311-1317, (2004)
[8]  
Eckhard M., Lommel D., Hackstein N., Et al., Disseminated periportal fatty degeneration after allogeneic intraportal islet transplantation in a patient with type 1 diabetes mellitus: A case report, Transplant Proc, 36, pp. 1111-1116, (2004)
[9]  
Sohn J., Siegelman E., Osiason A., Unusual patterns of hepatic steatosis caused by the local effect of insulin revealed on chemical shift MR imaging, AJR Am J Roentgenol, 176, pp. 471-474, (2001)
[10]  
Bulte J.W., Kraitchman D.L., Iron oxide MR contrast agents for molecular and cellular imaging, NMR Biomed, 17, pp. 484-499, (2004)