Salidroside attenuates hypoxia-induced pulmonary arterial smooth muscle cell proliferation and apoptosis resistance by upregulating autophagy through the AMPK-mTOR-ULK1 pathway

[11] Viollet B(2008)AMPK phosphorylation of raptor mediates a metabolic checkpoint Mol Cell 30 214-226

[12] Horman S(2012)Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells Gastroenterology 142 26-33

[13] Leclerc J(2011)Quercetin induces protective autophagy in gastric cancer cells: involvement of Akt-mTOR-and hypoxia-induced factor 1α-mediated signaling Autophagy 7 966-978

[14] Lantier L(2016)mTORC1 activation decreases autophagy in aging and idiopathic pulmonary fibrosis and contributes to apoptosis resistance in IPF fibroblasts Aging Cell 15 1103-1112

[15] Foretz M(2014)The metabolic basis of pulmonary arterial hypertension Cell Metab 19 558-573

[16] Billaud M(2009)Cardioprotection of salidroside from ischemia/reperfusion injury by increasing N-acetylglucosamine linkage to celluar proteins Eur J Pharmacol 613 93-99

[17] Wu YY(2010)A preliminary study: the anti-proliferation effect of salidroside on different human cancer cell lines Cell Biol Toxicol 26 499-507

[18] Liu L(2009)Plant adaptogens increase lifespan and stress resistance in C. Elegans Biogerontology 10 27-42

[19] Zhang YH(2009)The in vitro and in vivo antiviral effects of salidroside from Rhodiola Rosea L. against coxsackievirus B3 Phytomedicine 16 146-155

[20] Wang GZ(2009)Regulation mechanisms and signaling pathways of Autophagy Annu Rev Genet 43 67-93

[11] Viollet B(2008)AMPK phosphorylation of raptor mediates a metabolic checkpoint Mol Cell 30 214-226

[12] Horman S(2012)Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells Gastroenterology 142 26-33

[13] Leclerc J(2011)Quercetin induces protective autophagy in gastric cancer cells: involvement of Akt-mTOR-and hypoxia-induced factor 1α-mediated signaling Autophagy 7 966-978

[14] Lantier L(2016)mTORC1 activation decreases autophagy in aging and idiopathic pulmonary fibrosis and contributes to apoptosis resistance in IPF fibroblasts Aging Cell 15 1103-1112

[15] Foretz M(2014)The metabolic basis of pulmonary arterial hypertension Cell Metab 19 558-573

[16] Billaud M(2009)Cardioprotection of salidroside from ischemia/reperfusion injury by increasing N-acetylglucosamine linkage to celluar proteins Eur J Pharmacol 613 93-99

[17] Wu YY(2010)A preliminary study: the anti-proliferation effect of salidroside on different human cancer cell lines Cell Biol Toxicol 26 499-507

[18] Liu L(2009)Plant adaptogens increase lifespan and stress resistance in C. Elegans Biogerontology 10 27-42

[19] Zhang YH(2009)The in vitro and in vivo antiviral effects of salidroside from Rhodiola Rosea L. against coxsackievirus B3 Phytomedicine 16 146-155

[20] Wang GZ(2009)Regulation mechanisms and signaling pathways of Autophagy Annu Rev Genet 43 67-93