Salidroside attenuates hypoxia-induced pulmonary arterial smooth muscle cell proliferation and apoptosis resistance by upregulating autophagy through the AMPK-mTOR-ULK1 pathway

[1] Tuder RM(2007)Pathology of pulmonary hypertension Clin Chest Med 28 23-vii

[2] Marecki JC(2013)Pulmonary hypertension: pathology Handb Exp Pharmacol 218 59-75

[3] Richter A(2013)AMPK, insulin resistance, and the metabolic syndrome J Clin Invest 123 2764-2772

[4] Fijalkowska I(2010)AMPK inhibition in health and disease Crit Rev Biochem Mol 45 276-295

[5] Flores S(2014)Activation of AMPK inhibits pulmonary arterial smooth muscle cells proliferation Exp Lung Res 40 251-258

[6] Dorfmuller P(2014)Regulatory effect of AMP-activated protein kinase on pulmonary hypertension induced by chronic hypoxia in rats: in vivo and in vitro studies Mol Biol Rep 41 4031-4041

[7] Ruderman NB(2016)Salidroside exerts protective effects against chronic hypoxia-induced pulmonary arterial hypertension via AMPKα1-dependent pathways Am J Transl Res 8 12-27

[8] Carling D(2014)Inhibition of hypoxia-induced proliferation of pulmonary arterial smooth muscle cells by a mTOR siRNA-loaded cyclodextrin nanovector Biomaterials 35 4401-4416

[9] Prentki M(2011)mTOR is required for pulmonary arterial vascular smooth muscle cell proliferation under chronic hypoxia FASEB J 25 1922-1933

[10] Cacicedo JM(2003)TSC2 mediates cellular energy response to control cell growth and survival Cell 115 577-590

[1] Tuder RM(2007)Pathology of pulmonary hypertension Clin Chest Med 28 23-vii

[2] Marecki JC(2013)Pulmonary hypertension: pathology Handb Exp Pharmacol 218 59-75

[3] Richter A(2013)AMPK, insulin resistance, and the metabolic syndrome J Clin Invest 123 2764-2772

[4] Fijalkowska I(2010)AMPK inhibition in health and disease Crit Rev Biochem Mol 45 276-295

[5] Flores S(2014)Activation of AMPK inhibits pulmonary arterial smooth muscle cells proliferation Exp Lung Res 40 251-258

[6] Dorfmuller P(2014)Regulatory effect of AMP-activated protein kinase on pulmonary hypertension induced by chronic hypoxia in rats: in vivo and in vitro studies Mol Biol Rep 41 4031-4041

[7] Ruderman NB(2016)Salidroside exerts protective effects against chronic hypoxia-induced pulmonary arterial hypertension via AMPKα1-dependent pathways Am J Transl Res 8 12-27

[8] Carling D(2014)Inhibition of hypoxia-induced proliferation of pulmonary arterial smooth muscle cells by a mTOR siRNA-loaded cyclodextrin nanovector Biomaterials 35 4401-4416

[9] Prentki M(2011)mTOR is required for pulmonary arterial vascular smooth muscle cell proliferation under chronic hypoxia FASEB J 25 1922-1933

[10] Cacicedo JM(2003)TSC2 mediates cellular energy response to control cell growth and survival Cell 115 577-590