Cerebellar ataxia associated with anti-glutamic acid decarboxylase autoantibodies

被引：0
作者：
M. Vianello
B. Tavolato
M. Armani
B. Giometto
机构：
[1] University of Padova,Department of Neurological and Psychiatric Sciences (Second Clinic)
来源：
The Cerebellum | 2003年 / 2卷
关键词：
cerebellar ataxia; GAD antibodies; autoimmunity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Recent reports describe the detection of high titres of antibodies to glutamic acid decarboxylase (GAD-Ab) in the serum and cerebrospinal fluid (CSF) of patients with cerebellar ataxia. Most of these cases are females with Polyglandular Autoimmune Disorder who develop a chronic cerebellar syndrome. The CSF profile is in keeping with an autoimmune disorder and intrathecal GAD-Ab synthesis has been demonstrated. The ataxia could reverse after immunomodulatory treatments suggesting a possible pathogenetic role for GAD-Ab.
引用
收藏
页码：77 / 79
页数：2
相关论文
共 82 条
[1]  
Giometto B(1999)Autoimmunity in paraneoplastic neurological syndromes Brain Pathol 9 272-274
[2]  
Tavolato B(1995)Autoantibodies to glutamate decarboxylase in a patient with cerebellar cortical atrophy, peripheral neuropathy and slow eye movements Arch Neurol 52 462-468
[3]  
Graus F(1996)Anti-GABAergic neuron autoantibodies in a patient with stiff-man syndrome and ataxia J Neurol Sci 143 57-59
[4]  
Honnorat J(1997)Autoantibodies to glutamic acid decarboxylase in three patients with cerebellar ataxia, late-onset insulin-dependent diabetes mellitus and polyendocrine autoimmunity Neurology 49 1026-1030
[5]  
Trouillas P(1996)Glutamic acid decarboxylase—gene to antigen to disease J Intern Med 240 259-277
[6]  
Trivolet C(1993)Quantitative assay using recombinant human islet glutamic acid decarboxylase (GAD65) shows that 64 k antibody positivity at onset predicts diabetes type J Clin Invest 91 368-368
[7]  
Aguera M(1988)Autoantibodies to glutamic acid decarboxylase in a patient with stiff-man syndrome, epilepsy, and type 1 diabetes mellitus N Engl J Med 318 1012-1020
[8]  
Belin MF(1994)Autoantibodies to glutamic acid decarboxylase in palatal myoclonus and epilepsy Ann Neurol 36 665-667
[9]  
Giometto B(1998)Temporal-lobe epilepsy associated with glutamicacid-decarboxylase autoantibodies Lancet 352 457-457
[10]  
Miotto D(2000)Autoantibodies to glutamic acid decarboxylase in patients with therapy-resistant epilepsy Neurology 55 46-56
123456789