Stress, bacterial vaginosis, and the role of immune processes

被引:37
作者
Culhane J.F. [1 ]
Rauh V.A. [1 ]
Goldenberg R.L. [1 ]
机构
[1] Drexel University College of Medicine, Department of Obstetrics/Gynecology, Philadelphia, PA 19102
关键词
Preterm Birth; Black Woman; Obstet Gynecol; Bacterial Vaginosis; Psychosocial Stress;
D O I
10.1007/s11908-006-0020-x
中图分类号
学科分类号
摘要
Bacterial vaginosis (BV), the most common lower genital tract infection in women of reproductive age, is associated with adverse gynecologic and reproductive health outcomes. Women at highest risk for BV are young, unmarried, low income, undereducated, and African American. Behaviors such as vaginal douching, numerous sexual partners, frequent sexual intercourse, receptive oral sex, and substance use may contribute to risk, but they account for only a modest proportion of the observed race/ ethnicity variance in BV. These subpopulations are also exposed to more social disadvantages or "stressors" such as poverty, poor housing, crime-infested neighborhoods, and discrimination than other groups. Growing physiologic evidence links psychosocial stress to the development of disease. Evidence supports a statistically significant, independent effect of stress on the risk and observed racial/ethnic disparity in the rate of BV. This paper reviews such evidence. Copyright © 2006 by Current Science Inc.
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页码:459 / 464
页数:5
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共 63 条
  • [1] Hill G.B., The microbiology of bacterial vaginosis, Am J Obstet Gynecol, 169, pp. 450-454, (1993)
  • [2] Kimberlin D.F., Andrews W.W., Bacterial vaginosis: Association with adverse pregnancy outcome, Semin Perinatol, 22, pp. 242-250, (1998)
  • [3] Mead P.B., Epidemiology of bacterial vaginosis, Am J Obstet Gynecol, 169, pp. 446-449, (1993)
  • [4] Nansel T.R., Riggs M.A., Yu K.F., Et al., The association of psychosocial stress and bacterial vaginosis in a longitudinal cohort, Am J Obstet Gynecol, 194, pp. 381-386, (2006)
  • [5] Hillier S.L., Nugent R.P., Eschenbach D.A., Et al., Association between bacterial vaginosis and preterm delivery of a low birth weight infant, N Engl J Med, 333, pp. 1737-1742, (1995)
  • [6] Hay P.E., Morgan D.J., Ison C.A., Et al., A longitudinal study of bacterial vaginosis during pregnancy, Br J Obstet Gynaecol, 101, pp. 1048-1053, (1994)
  • [7] Llahi-Camp J.M., Rai R., Ison C., Et al., Association of bacterial vaginosis with a history of second trimester miscarriage, Hum Reprod, 11, pp. 1575-1578, (1996)
  • [8] Culhane J.F., Rauh V.R., McCollum K.F., Et al., Maternal stress is associated with bacterial vaginosis in human pregnancy, Mater Child Health, 5, pp. 127-134, (2001)
  • [9] McGregor J., French J.I., Bacterial vaginosis in pregnancy, Obstet Gynecol Surv, 55, 5 SUPPL. 1, (2000)
  • [10] Flynn C.A., Helwig A.L., Meurer L.N., Bacterial vaginosis in pregnancy and the risk of prematurity: A meta-analysis, J Fam Pract, 48, pp. 885-892, (1999)