Epigenetic Mistakes in Neurodevelopmental Disorders

被引：0
作者：
Giuseppina Mastrototaro
Mattia Zaghi
Alessandro Sessa
机构：
[1] San Raffaele Hospital,Division of Neuroscience
来源：
Journal of Molecular Neuroscience | 2017年 / 61卷
关键词：
Epigenetics; Neurodevelopmental disorders; Intellectual disability ;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Epigenetics is the array of the chromatin modifications that customize in cell-, stage-, or condition-specific manner the information encloses in plain DNA molecules. Increasing evidences suggest the importance of epigenetic mechanisms for development and maintenance of central nervous system. In fact, a large number of newly discovered genetic causes of neurodevelopmental disorders such as intellectual disability, autism spectrum disorders, and many other syndromes are mutations within genes encoding for chromatin remodeling enzymes. Here, we review recent findings on the epigenetic origin of human diseases, with emphasis on disorders that affect development of the nervous system, and discuss novel therapeutic avenues that target epigenetic mechanisms.
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页码：590 / 602
页数：12
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