Evolving strategies to overcome endocrine resistance in breast cancer

被引：0
|
作者：
Hubalek M. [1 ]
Brunner C. [1 ]
Marth C. [1 ]
机构：
[1] Department of Obstetrics and Gynecology, Brustgesundheitzentrum Tirol, Innsbruck Medical University, 6020 Innsbruck
来源：
memo - Magazine of European Medical Oncology | 2012年 / 5卷 / 2期
关键词：
Breast cancer; EGFR; Endocrine resistance; Farnesyltransferase inhibitors; HER2; Histone deacetylases inhibitors; IGF-R inhibitiors; MTOR-inhibitor; SRC-inhibitor;
D O I：
10.1007/s12254-012-0003-6
中图分类号：
学科分类号：
摘要：
Endocrine therapies targeting estrogen action decrease mortality from breast cancer, but their efficacy is limited by intrinsic and acquired therapeutic resistance. Various mechanisms can contribute to insensitivity toward endocrine treatment in hormone receptorpositive breast cancer patients. Definition of the specific genetic lesions and molecular processes that determine clinical endocrine resistance is still incomplete but recently tremendous advances have been made. In this short review the latest strategies to overcome endocrine resistance will be discussed. © Springer-Verlag Wien 2012.
引用
收藏
页码：105 / 109
页数：4
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