Synthetic fragments of the NS1 protein of the tick-borne encephalitis virus exhibiting a protective effect

被引：0
|
作者：
T. D. Volkova
D. O. Koroev
M. A. Titova
M. B. Oboznaya
M. P. Filatova
M. F. Vorovich
S. V. Ozherelkov
A. V. Timofeev
O. M. Volpina
机构：
[1] Russian Academy of Sciences,Shemyakin
[2] Russian Academy of Medical Sciences,Ovchinnikov Institute of Bioorganic Chemistry
来源：
Russian Journal of Bioorganic Chemistry | 2007年 / 33卷
关键词：
B epitopes; immunogenicity; NS1 nonstructural protein; protectivity; synthetic peptides; T helper epitopes; tick-borne encephalitis virus;
D O I：
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学科分类号：
摘要：
Potentially immunoactive regions of the NS1 nonstructural protein of the tick-borne encephalitis virus that can stimulate the antibody formation in vivo and protect animals from this disease were chosen on the basis of theoretical calculations. Eleven 16-to 27-aa peptides containing the chosen regions were synthesized. The ability of the free peptides (without any high-molecular-mass carrier) to stimulate the production of antipeptide antibodies in mice of three lines and ensure the formation of protective immunity was studied. Most of these peptides were shown to exhibit the immunogenic activity in a free state. Five fragments that can protect mice from the infection by a lethal dose of tick-borne encephalitis virus were found.
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页码：213 / 217
页数：4
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