Interferon-induced depression in hepatitis C: An update

被引：24
|
作者：
Keefe B. [1 ]
机构：
[1] Department of Psychiatry and Behavioral Sciences, University of South Florida, Tampa, FL 33613
来源：
Current Psychiatry Reports | 2007年 / 9卷 / 3期
关键词：
Depressive Symptom; Chronic Hepatitis; Paroxetine; Major Depressive Disorder; Sustained Viral Response;
D O I：
10.1007/s11920-007-0028-4
中图分类号：
学科分类号：
摘要：
Hepatitis C is a global epidemic, and its costs in both lives and health care expenditures continue to rise. The only approved treatment for this disease, interferon-alpha (IFN), causes treatment-emergent depression in more than one quarter of all patients who take it. Newer preparations of IFN have been developed to increase its antiviral efficacy, but the incidence of treatment-emergent depression has not decreased. The data on the epidemiology and risk factors for interferon-induced depression are reviewed in an effort to delineate its standing as a unique psychiatric disorder. In addition, evidence-based treatment approaches are outlined, including the potential efficacy of preinterferon prophylactic treatment with antidepressants. Copyright © 2007 by Current Medicine Group LLC.
引用
收藏
页码：255 / 261
页数：6
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