Signal transducer and activator of transcription 5 as a key signaling pathway in normal mammary gland developmental biology and breast cancer

被引：0

作者：

Priscilla A Furth

Rebecca E Nakles

Sarah Millman

Edgar S Diaz-Cruz

M Carla Cabrera

机构：

[1] Georgetown University,Department of Oncology, Lombardi Comprehensive Cancer Center

[2] Georgetown University,Department of Medicine

[3] Dankook University,World Class University Research Center of Nanobiomedical Science

来源：

Breast Cancer Research | / 13卷

关键词：

Breast Cancer Cell; Mammary Epithelial Cell; T47D Cell; Mammary Stem Cell; Normal Mammary Epithelial Cell;

D O I：

暂无

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学科分类号：

摘要：

STAT5 consists of two proteins, STAT5A/B, that impact mammary cell differentiation, proliferation, and survival. In normal development, STAT5 expression and activity are regulated by prolactin signaling with JAK2/ELF5, EGF signaling networks that include c-Src, and growth hormone, insulin growth factor, estrogen, and progesterone signaling pathways. In cancer, erythropoietin signaling can also regulate STAT5. Activation levels are influenced by AKT, caveolin, PIKE-A, Pak1, c-Myb, Brk, beta-integrin, dystroglycan, other STATs, and STAT pathway molecules JAK1, Shp2, and SOCS. TGF-β and PTPN9 can downregulate prolactin- and EGF-mediated STAT5 activation, respectively. IGF, AKT, RANKL, cyclin D1, BCL6, and HSP90A lie downstream of STAT5.

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