Synthesis and in vitro antimicrobial activity of new 3-(2-morpholinoquinolin-3-yl) substituted acrylonitrile and propanenitrile derivatives

被引：0
作者：
Jigar A. Makawana
Manish P. Patel
Ranjan G. Patel
机构：
[1] Sardar Patel University,Department of Chemistry
来源：
Chemical Papers | 2011年 / 65卷
关键词：
2-morpholinoquinoline; nitrile; antimicrobial activity; MIC;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A series of new 3-(2-morpholinoquinolin-3-yl)acrylonitrile derivatives (IVa-IVf) has been synthesised by the base-catalysed condensation reaction of 2-morpholinoqionoline-3-carboxaldehydes (IIa-IIc) and 2-cyanomethylbenzimidazoles (IIIa-IIIb). Subsequent regiospecific reduction of the C—C double bond in acrylonitrile moiety afforded 3-(2-morpholinoquinolin-3-yl)propanenitrile derivatives (Va-Vf). All the compounds synthesised were subjected to in vitro antimicrobial screening against some representatives of bacteria and fungi. The majority of the compounds were found to be active against Gram-positive bacteria Bacillus subtilis and Clostridium tetani as well as against the fungal pathogen Candida albicans.
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页码：700 / 706
页数：6
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