Lack of association between the interferon regulatory factor-1 (IRF1) locus at 5q31.1 and multiple sclerosis in Germany, Northern Italy, Sardinia and Sweden

被引：0

作者：

K Vandenbroeck

C Hardt

J Louage

P Fiten

S Jäckel

I Ronsse

JT Epplen

LME Grimaldi

T Olsson

MG Marrosu

A Billiau

G Opdenakker

机构：

[1] Rega Institute for Medical Research,Department of Molecular Human Genetics

[2] University of Leuven,Department of Neuroscience

[3] Institute for Human Genetics,undefined

[4] University Hospital of Essen,undefined

[5] Ruhr-University,undefined

[6] Neuroimmunology Unit,undefined

[7] San Raffaele Scientific Institute,undefined

[8] Neuroimmunology Unit,undefined

[9] Center for Molecular Medicine,undefined

[10] Karolinska Hospital,undefined

[11] University of Cagliari,undefined

来源：

Genes & Immunity | 2000年 / 1卷

关键词：

genetics; interferon; linkage; multiple sclerosis; polymorphism;

D O I：

暂无

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学科分类号：

摘要：

Interferon regulatory factor-1 (IRF-1) is a transcriptional inducer of the interferon-β (IFN-β) gene and other interferon-stimulated genes. A GT repeat polymorphism in the 7th intron of the IRF-1 gene was used as a marker to test for association with multiple sclerosis (MS) in a case-control study including individuals from Germany, Northern Italy and Sweden. In none of these populations, did we find any significant allelic association with disease. This lack of association was confirmed by testing transmission disequilibrium of individual IRF1 alleles in a representative sample of Sardinian simplex MS families. No deviation of the expected 50% transmission rates was seen. Therefore, our work does not provide evidence in favor of IRF1 being a candidate for conferring genetic susceptibility to, or protection against, MS in Europe.

引用

页码：290 / 292

页数：2