Metformin protects human lens epithelial cells from high glucose-induced senescence and autophagy inhibition by upregulating SIRT1

[1] Albert-Garay JS(2022)High glucose concentrations induce oxidative stress by inhibiting Nrf2 expression in rat Muller retinal cells in vitro Sci Rep 12 1261-543

[2] Riesgo-Escovar JR(2012)Metformin reduces endogenous reactive oxygen species and associated DNA damage Cancer Prev Res (Phila) 5 536-8389

[3] Salceda R(2022)Long term high glucose exposure induces premature senescence in retinal endothelial cells Front Physiol 13 929118-C503

[4] Algire C(2022)Metformin protects lens epithelial cells against senescence in a naturally aged mouse model Cell Death Dis 8 8-827

[5] Moiseeva O(2021)Metformin alleviates oxidative stress-induced senescence of human lens epithelial cells via AMPK activation and autophagic flux restoration J Cell Mol Med 25 8376-979

[6] Deschenes-Simard X(2018)Disruption of the lens circulation causes calcium accumulation and precipitates in connexin mutant mice Am J Physiol Cell Physiol 314 C492-1592

[7] Amrein L(2019)Cellular senescence: defining a path forward Cell 179 813-466

[8] Petruccelli L(2013)The sirtuin family's role in aging and age-associated pathologies J Clin Invest 123 973-1128

[9] Birman E(2018)Anti-cataract effect of resveratrol in high-glucose-treated streptozotocin-induced diabetic rats Biol Pharm Bull 41 1586-153

[10] Viollet B(2015)Deacetylation of nuclear LC3 drives autophagy initiation under starvation Mol Cell 57 456-30

[1] Albert-Garay JS(2022)High glucose concentrations induce oxidative stress by inhibiting Nrf2 expression in rat Muller retinal cells in vitro Sci Rep 12 1261-543

[2] Riesgo-Escovar JR(2012)Metformin reduces endogenous reactive oxygen species and associated DNA damage Cancer Prev Res (Phila) 5 536-8389

[3] Salceda R(2022)Long term high glucose exposure induces premature senescence in retinal endothelial cells Front Physiol 13 929118-C503

[4] Algire C(2022)Metformin protects lens epithelial cells against senescence in a naturally aged mouse model Cell Death Dis 8 8-827

[5] Moiseeva O(2021)Metformin alleviates oxidative stress-induced senescence of human lens epithelial cells via AMPK activation and autophagic flux restoration J Cell Mol Med 25 8376-979

[6] Deschenes-Simard X(2018)Disruption of the lens circulation causes calcium accumulation and precipitates in connexin mutant mice Am J Physiol Cell Physiol 314 C492-1592

[7] Amrein L(2019)Cellular senescence: defining a path forward Cell 179 813-466

[8] Petruccelli L(2013)The sirtuin family's role in aging and age-associated pathologies J Clin Invest 123 973-1128

[9] Birman E(2018)Anti-cataract effect of resveratrol in high-glucose-treated streptozotocin-induced diabetic rats Biol Pharm Bull 41 1586-153

[10] Viollet B(2015)Deacetylation of nuclear LC3 drives autophagy initiation under starvation Mol Cell 57 456-30