Relevance of somatostatin receptors and other peptide receptors in pathology

被引：0
作者：
Jean Claude Reubi
机构：
[1] University of Berne,Division of Cell Biology and Experimental Cancer Research, Institute of Pathology
来源：
Endocrine Pathology | 1997年 / 8卷
关键词：
Regulatory peptide receptors; tumors; peritumoral vessels; somatostatin; receptor autoradiography;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Receptors for regulatory peptides can be overexpressed by several diseases, in particular by neoplasms. This review summarizes the current status of knowledge in this field, on the basis of in vitro receptor studies and with emphasis on receptors for somatostatin as well as for substance P (SP), vasoactive intestinal polypeptide (VIP), and cholecystokinin. It evaluates the existing and potential clinical implications of the findings for diagnosis and therapy and discusses the role of the pathologist in this context.
引用
收藏
页码：11 / 20
页数：9
相关论文
共 131 条
  • [1] Reubi JC(1995)Neuropeptide receptors in health and disease: the molecular basis for in vivo imaging J Nucl Med 36 1825-1835
  • [2] Lamberts SWJ(1991)The role of somatostatin and its analogs in the diagnosis and treatment of tumors Endocr Rev 12 450-482
  • [3] Krenning EP(1995)Classification and nomenclature of somatostatin receptors Trends in Pharmacol Sci 16 86-88
  • [4] Reubi JC(1995)Molecular biology of somatostatin receptors Endocr Rev 16 427-442
  • [5] Hoyer D(1992)In vitro detection of somatostatin receptors in human tumors Metabolism 41 104-110
  • [6] Bell GI(1994)Expression and localization of somatostatin receptor SSTR1, SSTR2 and SSTR3 mRNAs in primary human tumors using in situ hybridization Cancer Res 54 3455-3459
  • [7] Berelowitz M(1994)Expression of three somatostatin receptor subtypes in pituitary adenomas: evidence for preferential SSTR5 expression in the mammosomatotroph lineage J Clin Endocrinol Metab 79 724-729
  • [8] Epelbaum J(1996)Induction of a negative autocrine loop by expression of sst2 somatostatin receptor in NIH 3T3 cells J Clin Invest 97 1874-1883
  • [9] Feniuk W(1995)Somatostatin receptors in human prostate and prostate cancer J Clin Endocrinol Metab 80 2806-2814
  • [10] Humphrey PPA(1996)Loss of sst2 somatostatin receptor gene expression in human pancreatic and colorectal cancer Cancer Res 56 1823-1827
12345678910