Key molecular mechanisms associated with cell malignant transformation in acute myeloid leukemia

被引：0
|
作者：
N. N. Orlova
T. D. Lebedev
P. V. Spirin
V. S. Prassolov
机构：
[1] Russian Academy of Sciences,Engelhardt Institute of Molecular Biology
来源：
Molecular Biology | 2016年 / 50卷
关键词：
acute myeloid leukemia; cancer; signaling pathways; apoptosis; DNA repair; JNK; TGF-β; p38; Hedgehog;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Cancer, along with cardiovascular disorders, is one of the most important problems of healthcare. Pathologies of the hematopoietic system are the most prevalent in patients under 30 years of age, including acute myeloid leukemia (AML), which is widespread and difficult to treat. The review considers the mechanisms that play a significant role in AML cell malignant transformation and shows the contributions of certain genes to both remission and resistance of AML cells to various treatments.
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页码：344 / 352
页数：8
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