Targeting MCL-1 in cancer: current status and perspectives

被引：0
作者：
Haolan Wang
Ming Guo
Hudie Wei
Yongheng Chen
机构：
[1] Central South University,Department of Oncology, NHC Key Laboratory of Cancer Proteomics, Laboratory of Structural Biology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital
[2] Central South University,National Clinical Research Center for Geriatric Disorders, Xiangya Hospital
来源：
Journal of Hematology & Oncology | / 14卷
关键词：
MCL-1; BCL-2 family; Cancer; Apoptosis; Inhibitor;
D O I：
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摘要：
Myeloid leukemia 1 (MCL-1) is an antiapoptotic protein of the BCL-2 family that prevents apoptosis by binding to the pro-apoptotic BCL-2 proteins. Overexpression of MCL-1 is frequently observed in many tumor types and is closely associated with tumorigenesis, poor prognosis and drug resistance. The central role of MCL-1 in regulating the mitochondrial apoptotic pathway makes it an attractive target for cancer therapy. Significant progress has been made with regard to MCL-1 inhibitors, some of which have entered clinical trials. Here, we discuss the mechanism by which MCL-1 regulates cancer cell apoptosis and review the progress related to MCL-1 small molecule inhibitors and their role in cancer therapy.
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