ifn-γ-dependent secretion of IL-10 from Th1 cells and microglia/macrophages contributes to functional recovery after spinal cord injury

被引：0

作者：

H Ishii

S Tanabe

M Ueno

T Kubo

H Kayama

S Serada

M Fujimoto

K Takeda

T Naka

T Yamashita

机构：

[1] Graduate School of Medicine,Department of Molecular Neuroscience

[2] Osaka University,Department of Neurobiology

[3] 2-2 Yamadaoka,Department of Microbiology and Immunology

[4] Osaka 565-0871,undefined

[5] Japan,undefined

[6] JST,undefined

[7] CREST,undefined

[8] 5 Sanbancho,undefined

[9] Graduate School of Medicine,undefined

[10] Chiba University,undefined

[11] 1-8-1 Inohana,undefined

[12] Chiba 260-8677,undefined

[13] Japan,undefined

[14] Laboratory of Mucosal Immunology,undefined

[15] Graduate School of Medicine,undefined

[16] Osaka University,undefined

[17] 2-2 Yamadaoka,undefined

[18] Osaka 565-0871,undefined

[19] Japan,undefined

[20] WPI Immunology Frontier Research Center,undefined

[21] Osaka University,undefined

[22] 2-2 Yamadaoka,undefined

[23] Osaka 565-0871,undefined

[24] Japan,undefined

[25] Laboratory for Immune Signal,undefined

[26] National Institute of Biomedical Innovation,undefined

[27] 7-6-8 Saito-Asagi,undefined

[28] Osaka 565-0085,undefined

[29] Japan,undefined

来源：

Cell Death & Disease | 2013年 / 4卷

关键词：

Th1 cells; spinal cord injury; microglia macrophages; interleukin 10;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Transfer of type-1 helper T-conditioned (Th1-conditioned) cells promotes functional recovery with enhanced axonal remodeling after spinal cord injury (SCI). This study explored the molecular mechanisms underlying the beneficial effects of pro-inflammatory Th1-conditioned cells after SCI. The effect of Th1-conditioned cells from interferon-γ (ifn-γ) knockout mice (ifn-γ−/− Th1 cells) on the recovery after SCI was reduced. Transfer of Th1-conditioned cells led to the activation of microglia (MG) and macrophages (MΦs), with interleukin 10 (IL-10) upregulation. This upregulation of IL-10 was reduced when ifn-γ−/− Th1 cells were transferred. Intrathecal neutralization of IL-10 in the spinal cord attenuated the effects of Th1-conditioned cells. Further, IL-10 is robustly secreted from Th1-conditioned cells in an ifn-γ-dependent manner. Th1-conditioned cells from interleukin 10 knockout (il-10−/−) mice had no effects on recovery from SCI. These findings demonstrate that ifn-γ-dependent secretion of IL-10 from Th1 cells, as well as native MG/MΦs, is required for the promotion of motor recovery after SCI.

引用

页码：e710 / e710

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