The IL-33 gene is related to increased susceptibility to systemic sclerosis

被引:0
作者
Suleyman Serdar Koca
Yavuz Pehlivan
Murat Kara
Fatma Alibaz-Oner
Serdar Oztuzcu
Neslihan Yilmaz
Gozde Yildirim Cetin
Bunyamin Kisacik
Metin Ozgen
Omer Nuri Pamuk
Haner Direskeneli
Mehmet Sayarlioglu
Ahmet Mesut Onat
机构
[1] Firat University,Department of Rheumatology, Faculty of Medicine
[2] Uludag University,Department of Rheumatology, Faculty of Medicine
[3] Sitki Kocman University,Department of Medical Genetics, Faculty of Medicine
[4] Marmara University,Department of Rheumatology, Faculty of Medicine
[5] Gaziantep University,Department of Medical Genetics, Faculty of Medicine
[6] Sisli Florence Nightingale Hospital,Department of Rheumatology
[7] Sutcu Imam University,Department of Rheumatology, Faculty of Medicine
[8] Gaziantep University,Department of Rheumatology, Faculty of Medicine
[9] 19 Mayis University,Department of Rheumatology, Faculty of Medicine
[10] Trakya University,Department of Rheumatology, Faculty of Medicine
来源
Rheumatology International | 2016年 / 36卷
关键词
Systemic sclerosis; Genetic; IL-33 gene polymorphism;
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摘要
Systemic sclerosis (SSc) is a chronic inflammatory disease characterized by widespread fibrosis of the skin and several visceral organs. The pro-fibrotic potential of interleukin (IL)-33 has been demonstrated by in both in vitro and in vivo settings; moreover, increased level of IL-33 has also been reported in patients with SSc. Therefore, the aim of the present study was to detect the potential association of IL-33 gene polymorphisms on the susceptibility of SSc. A total of 300 SSc patients and 280 healthy controls (HC) were enrolled in this multicentric preliminary candidate gene study. DNA samples were harvested using an appropriate commercial DNA isolation kit. Four single nucleotide polymorphisms (SNPs) of IL-33 gene (rs7044343, rs1157505, rs11792633 and rs1929992) were genotyped using the appropriate commercial primer/probe sets on real-time PCR. There was no significant difference in terms of the allelic distributions and minor allele frequencies of evaluated four IL-33 polymorphisms between the SSc and HC groups (P > 0.05 for all). Moreover, the genotypic distributions of rs1157505, rs11792633 and rs1929992 polymorphisms were not significantly different (P > 0.05 for all). However, CC genotype of rs7044343 SNP was significantly higher in the SSc group compared to the HC group (P = 0.013, OR 1.75, 95 % CI 1.12–2.72). This preliminary candidate gene study demonstrates that rs7044343 polymorphism of IL-33 gene is associated with the susceptibility to the SSc in Turkish population. It may be suggested that IL-33 gene may be a candidate gene to research in SSc.
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页码:579 / 584
页数:5
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共 213 条
[1]  
Greenblatt MB(2013)The immune pathogenesis of scleroderma: context is everything Curr Rheumatol Rep 15 297-549
[2]  
Aliprantis AO(2011)Role of IL-13 in systemic sclerosis Cytokine 56 544-490
[3]  
Fuschiotti P(2005)IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines Immunity 23 479-2987
[4]  
Schmitz J(2002)Activated, but not resting human Th2 cells, in contrast to Th1 and T regulatory cells, produce soluble ST2 and express low levels of ST2L at the cell surface Eur J Immunol 32 2979-160
[5]  
Owyang A(2010)IL-33 and IL-33 receptors in host defense and diseases Allergol Int 59 143-2786
[6]  
Oldham E(2007)IL-33 is a chemoattractant for human Th2 cells Eur J Immunol 37 2779-594
[7]  
Song Y(2004)Fibrotic disease and the T(H)1/T(H)2 paradigm Nat Rev Immunol 4 583-332
[8]  
Murphy E(1997)Elevated serum levels of interleukin 4 (IL-4), IL-10, and IL-13 in patients with systemic sclerosis J Rheumatol 24 328-72
[9]  
McClanahan TK(1992)Interleukin-1, interleukin-2, interleukin-4, interleukin-6, tumor necrosis factor alpha, and interferon-gamma levels in sera from patients with scleroderma Arthritis Rheum 35 67-1758
[10]  
Zurawski G(1997)Type 2 helper T-cell predominance and high CD30 expression in systemic sclerosis Am J Pathol 151 1751-1535