New and Emerging Therapies for Pulmonary Complications of Cystic Fibrosis

被引：0
作者：
Mark R. Tonelli
Moira L. Aitken
机构：
[1] University of Washington,Division of Pulmonary and Critical Care Medicine Department of Medicine
[2] UWMC,undefined
来源：
Drugs | 2001年 / 61卷
关键词：
Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Colistin; Early Clinical Trial; Pulmonary Exacerbation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In the decade since the gene for cystic fibrosis (CF) was discovered, research into potential therapeutic interventions has progressed on a number of different fronts. The vast majority of morbidity and mortality in CF results from inflammation and infection of the airways. Direct delivery of antibacterials to the airway secretions via a nebuliser is an attractive therapeutic option, and a novel formulation of tobramycin designed for such a purpose has been demonstrated to improve spirometry and decrease the need for intravenous antibacterials. In addition, early clinical trials are studying the effects of small peptides with antibiotic properties (defensins) delivered directly to the airways.
引用
收藏
页码：1379 / 1385
页数：6
相关论文
共 95 条
  • [1] Ramsey BW(1996)Management of pulmonary disease in patients with cystic fibrosis N Engl J Med 18 179-88
  • [2] Ramsey B(1999)Intermittent administration of inhaled tobramycin in patients with cystic fibrosis N Engl JMed 340 23-30
  • [3] Pepe M(1999)Effect of chronic intermittent administration of inhaled tobramycin on respiratory microbial flora in patients with cystic fibrosis J Infect Dis 179 1190-6
  • [4] Quan J(1997)Effect of tonicity of nebulised colistin on chest tightness and pulmonary function in adults with cystic fibrosis Thorax 52 656-8
  • [5] Burns J(1987)Colistin inhalation therapy in cystic fibrosis patients with chronic J Antimicrob Chemother 19 831-8
  • [6] Van Dalfsen J(1997) lung infection Transplantation 64 748-52
  • [7] Shawar R(1996)Use of aerosolized colistin sodium in cystic fibrosis patients awaiting lung transplantation Cell 85 229-36
  • [8] Dodd M(1997)Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal surface fluid Pediatr Pulmonol 24 137-42
  • [9] Abbott J(1995)Current understanding of the inflammatory process in cystic fibrosis Thorax 50 1246-52
  • [10] Maddison J(1991)Long term effect of erythromycin therapy in patients with chronic Pediatrics 87 245-6
12345678910