Heart rate variability analysis in sheep affected by transmissible spongiform encephalopathies

被引：8
作者：
Konold T. [1 ]
Bone G.E. [1 ]
机构：
[1] Pathology and Host Susceptibility, Neuropathology, Animal Health and Veterinary Laboratories Agency Weybridge, New Haw, Addlestone
来源：
BMC Research Notes | / 4卷 / 1期
关键词：
Heart Rate Variability; Bovine Spongiform Encephalopathy; Scrapie; Heart Rate Variability Analysis; Heart Rate Variability Index;
D O I：
10.1186/1756-0500-4-539
中图分类号：
学科分类号：
摘要：
Background: The function of the autonomic nervous system can be assessed by determining heart rate variability (HRV), which is impaired in some brainstem diseases in humans. Transmissible spongiform encephalopathies (TSEs) in sheep are diseases characterised by accumulation of disease-associated prion protein in the brainstem, including nuclei of the parasympathetic nervous system. This study was undertaken to assess whether analysis of HRV can be used as an aid in the diagnosis of TSEs in clinically affected, naturally or experimentally infected sheep. Findings. When HRV indices were compared between 41 clinical TSE cases (18 sheep infected with scrapie and 23 sheep infected with bovine spongiform encephalopathy), 11 control sheep and six sheep reported as scrapie suspects or dosed with BSE brain homogenate, which were not confirmed as TSE cases by postmortem tests, no significant differences were found between the groups. Median heart rate was significantly different but only when sheep were grouped by gender: it was higher in female TSE cases than in control sheep and higher in female than castrated male ovine classical BSE cases. Conclusions: HRV analysis was not useful as a diagnostic aid for TSEs of sheep. © 2011 Crown; licensee BioMed Central Ltd.
引用
收藏
相关论文
共 30 条
[1]  
Jeffrey M., Ryder S., Martin S., Hawkins S.A.C., Terry L., Berthelin-Baker C., Bellworthy S.J., Oral inoculation of sheep with the agent of bovine spongiform encephalopathy (BSE). 1. Onset and distribution of disease-specific PrP accumulation in brain and viscera, Journal of Comparative Pathology, 124, 4, pp. 280-289, (2001)
[2]  
Ryder S.J., Spencer Y.I., Bellerby P.J., March S.A., Immunohistochemical detection of PrP in the medulla oblongata of sheep: The spectrum of staining in normal and scrapie-affected sheep, Vet Rec, 148, pp. 7-13, (2001)
[3]  
De Lahunta A., Glass E., Lower motor neuron: General visceral efferent system, Veterinary Neuroanatomy and Clinical Neurology, pp. 168-191, (2009)
[4]  
Berntson G.G., Cacioppo J.T., Quigley K.S., Respiratory sinus arrhythmia: Autonomic origins, physiological mechanisms, and psychophysiological implications, Psychophysiology, 30, 2, pp. 183-196, (1993)
[5]  
Van Ravenswaaij-Arts C.M.A., Kollee L.A.A., Hopman J.C.W., Stoelinga G.B.A., Van Geijn H.P., Heart rate variability, Annals of Internal Medicine, 118, 6, pp. 436-447, (1993)
[6]  
Monge Argiles J.A., Palacios Ortega F., Vila Sobrino J.A., Bautista Prados J., Perez Vicente J.A., Morales Ortiz A., Palao Sanchez A., Las lesiones del troncoencefalo disminuyen la variabilidad de la frecuencia cardiaca, Neurologia, 15, 4, pp. 158-163, (2000)
[7]  
Korpelainen J.T., Huikuri H.V., Sotaniemi K.A., Myllyla V.V., Abnormal heart rate variability reflecting autonomic dysfunction in brainstem infarction, Acta Neurologica Scandinavica, 94, 5, pp. 337-342, (1996)
[8]  
Konold T., Bone G.E., Simmons M.M., Time and frequency domain analysis of heart rate variability in cattle affected by bovine spongiform encephalopathy, BMC Res Notes, 4, (2011)
[9]  
Glover D.G., Pollard B.J., Gonzalez L., Siso S., Kennedy D., Jeffrey M., A non-invasive screen for infectivity in transmissible spongiform encephalopathies [13], Gut, 56, 9, pp. 1329-1330, (2007)
[10]  
Konold T., Sayers R., Bellworthy S., Assessment of heart rate variability analysis in the diagnosis of transmissible spongiform encephalopathies in sheep. Abstract from a presentation at the 17th Annual Congress of the European Society of Veterinary Neurology, Glasgow, 23-25 September 2004, J Vet Intern Med, 19, (2005)
123