Intratumoural lymphatics in benign and malignant soft tissue tumours

被引:0
作者
G. Mahendra
K. Kliskey
K. Williams
K. Hollowood
D. Jackson
N. A. Athanasou
机构
[1] University of Oxford,Department of Pathology, Nuffield Department of Orthopaedic Surgery
[2] Nuffield Orthopaedic Centre,Department of Cellular Pathology
[3] John Radcliffe Hospital,Institute of Molecular Medicine, C/
[4] University of Oxford, John Radcliffe Hospital
来源
Virchows Archiv | 2008年 / 453卷
关键词
Lymphatics; Sarcoma; Benign soft tissue tumours;
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学科分类号
摘要
Soft tissue sarcomas do not generally metastasise via lymphatics, and the presence or absence of lymphatic vessels within sarcomas and benign soft tissue tumours is not known. In this study, we determined whether lymphatic vessels were present in a wide range of benign and malignant soft tissue lesions by examining intratumoural expression of the lymphatic endothelial cell markers, Lyve-1 and podoplanin. Intratumoural Lyve-1+/podoplanin+ lymphatics were not identified in sarcomas apart from all cases of epithelioid sarcoma (a tumour which is known to metastasise to lymph nodes) and a few cases of leiomyosarcoma, rhabdomyosarcoma and synovial sarcoma. Intratumoural lymphatics were also absent in most benign soft tissue tumours. Reparative and inflammatory soft tissue lesions contained lymphatics, as did all (pseudosarcomatous) proliferative myofibroblastic lesions including nodular, proliferative and ischaemic fasciitis, elastofibroma, nuchal fibroma and deep fibromatosis. Our results show that most soft tissue sarcomas do not contain intratumoural lymphatics, a finding which is consistent with the infrequent finding of sarcoma metastasis to lymph nodes. In contrast to fibrosarcoma and a number of other malignant spindle cell tumours, proliferative fibroblastic/myofibroblastic lesions of soft tissue contain intralesional lymphatic vessels.
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页码:457 / 464
页数:7
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