Chiral Separation of 4-Iminoflavan Derivatives on Several Polysaccharide-Based Chiral Stationary Phases by HPLC

被引：0

作者：

Ismahan Rahou

Nasser Belboukhari

Khaled Sekkoum

Abdelkarim Cheriti

Hassan Y. Aboul-Enein

机构：

[1] University of Bechar,Bioactive Molecules and Chiral Separation Laboratory, Faculty of Science and Technology

[2] University of Bechar,Phytochemistry and Organic Synthesis Laboratory, Faculty of Science and Technology

[3] National Research Center,Pharmaceutical and Medicinal Chemistry Department, Pharmaceutical and Drug Industries Research Division

来源：

Chromatographia | 2014年 / 77卷

关键词：

Column liquid chromatography; Polysaccharide-based chiral stationary phases; Chiral separation; -Aryl 4-iminoflavans;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The HPLC enantiomeric separation of seven 4-iminoflavans was successfully accomplished in the normal phase mode using six polysaccharide-based chiral stationary phases namely, Chiralcel®OD-H, Chiralcel®OD, Chiralcel®OJ, Chiralpak®AD, Chiralpak®IA and Chiralpak®IB under normal and polar organic phase modes. The resolution depended on nature and concentration of alcoholic modifier. The results demonstrate clearly that the chromatographic system based on the coated and immobilized type Chiralpak®IB and Chiralcel®OD-H CSPs provide a powerful analytical tool for enantiomeric separation of all the 4-iminoflavans used in this study.

引用

收藏

页码：1195 / 1201

页数：6

相关论文

共 50 条

[31] HPLC chiral stationary phases based on a glycoprotein [J].

Haginaka, J .

TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY, 1997, 9 (49) :399-407

[32] Chiral Resolution of Enantiomers of Homocamptothecin Derivatives, Antitumor Topoisomerase I Inhibitors, Using High Performance Liquid Chromatography on Polysaccharide-Based Chiral Stationary Phases [J].

J.F. Goossens ;

C. Foulon ;

C. Bailly ;

D.C.H. Bigg ;

J.P. Bonte ;

C. Vaccher .

Chromatographia, 2004, 59 :305-313

[33] Chiral resolution of enantiomers of homocamptothecin derivatives, antitumor topoisomerase I inhibitors, using high performance liquid chromatography on polysaccharide-based chiral stationary phases [J].

Goossens, JF ;

Foulon, C ;

Bailly, C ;

Bigg, DCH ;

Bonte, JP ;

Vaccher, C .

CHROMATOGRAPHIA, 2004, 59 (5-6) :305-313

[34] Possibilities and limitations of computer assisted chiral HPLC method development for ozanimod on polysaccharide based chiral stationary phases [J].

Ferencz, Elek ;

Szabo, Zoltan-Istvan ;

Zoldhegyi, Arnold ;

Dombi, Gergely ;

Molnar, Gergely ;

Dobo, Mate ;

Varga, Erzsebet ;

Molnar, Imre ;

Toth, Gergo .

SCIENTIFIC REPORTS, 2024, 14 (01)

[35] Enantioseparation of 1-Phenyl-1,2,3,4-tetrahydroisoquinoline on Polysaccharide-Based Chiral Stationary Phases [J].

Helena Kažoka ;

Oksana Rotkaja ;

Larisa Varačeva .

Chromatographia, 2011, 73 :123-129

[36] Enantioseparation of 1-Phenyl-1,2,3,4-tetrahydroisoquinoline on Polysaccharide-Based Chiral Stationary Phases [J].

Kazoka, Helena ;

Rotkaja, Oksana ;

Varaceva, Larisa .

CHROMATOGRAPHIA, 2011, 73 :S123-S129

[37] Comparative studies of immobilized chiral stationary phases based on polysaccharide derivatives for enantiomeric separation of 15 azole compounds [J].

Zhu, Bolin ;

Deng, Miaoduo ;

Yao, Yaqi ;

Yu, Jia ;

Li, Qing .

ELECTROPHORESIS, 2018, 39 (16) :2107-2116

[38] Study of the enantiomeric separation of an acetamide intermediate by using supercritical fluid chromatography and several polysaccharide based chiral stationary phases [J].

Toribio, L. ;

del Nozal, M. J. ;

Bernal, J. L. ;

Bernal, J. ;

Martin, M. T. .

JOURNAL OF CHROMATOGRAPHY A, 2011, 1218 (30) :4886-4891

[39] HPLC separation of enantiomers of chiral arylpropionic acid derivatives using polysaccharide-based chiral columns and normal-phase eluents with emphasis on elution order [J].

Matarashvili, Iza ;

Chankvetadze, Lali ;

Fanali, Salvatore ;

Farkas, Tivadar ;

Chankvetadze, Bezhan .

JOURNAL OF SEPARATION SCIENCE, 2013, 36 (01) :140-147

[40] Chiral separation of novel diazenes on a polysaccharide-based stationary phase in the reversed-phase mode [J].

Vojtylova, Terezia ;

Hamplova, Vera ;

Galewski, Zbigniew ;

Korbecka, Izabela ;

Sykora, David .

JOURNAL OF SEPARATION SCIENCE, 2017, 40 (07) :1465-1469

← 1 2 3 4 5 →