Crossed cerebellar diaschisis: a positron emission tomography study withl-[methyl-11C]methionine and 2-deoxy-2-[18F]fluoro-d-glucose

被引:0
作者
Katsufumi Kajimoto
Naohiko Oku
Yasuyuki Kimura
Hiroki Kato
Makiko Rai Tanaka
Yasukazu Kanai
Kazuo Kitagawa
Motohiko Maruno
Toshiki Yoshimine
Masatsugu Hori
Jun Hatazawa
机构
[1] Osaka University Graduate School of Medicine,Department of Nuclear Medicine and Tracer Kinetics
[2] Osaka University Graduate School of Medicine,Department of Cardiovascular Medicine
[3] Osaka University Graduate School of Medicine,Department of Neurosurgery
来源
Annals of Nuclear Medicine | 2007年 / 21卷
关键词
crossed cerebellar diaschisis; 2-deoxy-2-[; F]fluoro-; -glucose; -[methyl-; C]methionine; positron emission tomography;
D O I
暂无
中图分类号
学科分类号
摘要
Objective: Crossed cerebellar diaschisis (CCD) is defined as a depression of blood flow and oxidative metabolism of glucose in the cerebellum contralateral to a supratentorial brain lesion, as detected with positron emission tomography (PET) and single photon emission computed tomography. We examined whetherl-[methyl-11C]methionine (MET) uptake is affected in CCD.Methods: In 12 patients with a unilateral supratentorial brain tumor, we evaluated the uptake of 2-deoxy-2-[18F]fluoroe-d-glucose (FDG) and MET in the cerebellar hemispheres by means of PET. Asymmetry index (AI) was defined as a difference in the average count between the ipsilateral and contralateral cerebellar hemispheres divided by the average count in both cerebellar hemispheres. Patients with AI of FDG PET more than 0.1 and those with AI equal to 0.1 or less than 0.1 were classified as CCD-positive and CCD-negative, respectively.Results: Six patients were CCD-positive and others were CCD-negative in the FDG PET study. Between CCD-positive and CCD-negative patients, mean AI of MET was not significantly different (0.017±0.023 and 0.014±0.039, respectively).Conclusions: Different from glucose metabolism, cerebellar MET uptake was not affected in CCD. The present study may indicate that cerebellar MET uptake is independent of suppression of cerebellar neuronal activity.
引用
收藏
页码:109 / 113
页数:4
相关论文
共 86 条
[1]  
Baron JC(1980)“Crossed cerebellar diaschisis” in human supratentorial brain infarction Trans Am Neurol Assoc 105 459-461
[2]  
Bousser MG(1984)Depressed cerebellar glucose metabolism in supratentorial tumors Brain Res 291 93-101
[3]  
Comar D(1997)Fluorine-18-FDG evaluation of crossed cerebellar diaschisis in head injury J Nucl Med 38 1717-1720
[4]  
Castaigne P(1995)Crossed cerebellar diaschisis related to recurrent focal seizures Epilepsia 36 316-318
[5]  
Patronas NJ(2002)Neuronal deactivation explains decreased cerebellar blood flow in response to focal cerebral ischemia or suppressed neocortical function Proc Natl Acad Sci USA 99 7699-7704
[6]  
Di Chiro G(1992)Hemodynamic and metabolic changes in crossed cerebellar hypoperfusion Stroke 23 855-860
[7]  
Smith BH(2002)Hemodynamic changes during neural deactivation in human brain: a positron emission tomography study of crossed cerebellar diaschisis Ann Nucl Med 16 249-254
[8]  
De La Paz R(1976)Labelling and metabolism of methionine-methyl- Eur J Nucl Med 1 11-14
[9]  
Brooks RA(1992)C J Neurochem 59 1437-1443
[10]  
Milam HL(1997)Brain protein synthesis in the conscious rat using J Child Neurol 12 407-414