Pluripotency maintenance mechanism of embryonic stem cells and reprogramming

被引：0
作者：
Shinji Masui
机构：
[1] International Medical Center of Japan,Division of Molecular Biology and Cell Engineering, Department of Regenerative Medicine, Research Institute
[2] PRESTO,undefined
[3] Japan Science and Technology Agency,undefined
来源：
International Journal of Hematology | 2010年 / 91卷
关键词：
Pluripotency; ES cells; Transcriptional network;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Embryonic stem (ES) cells are derived from blastocysts and are pluripotent. This pluripotency has attracted the interest of numerous researchers, both to expand our fundamental understanding of developmental biology and also because of potential applications in regenerative medicine. Systems biological studies have demonstrated that the pivotal transcription factors form a network. There they activate pluripotency-associated genes, including themselves, while repressing the developmentally regulated genes through co-occupation with various protein complexes. The chromatin structure characteristic of ES cells also contributes to the maintenance of the network. In this review, I focus on recent advances in our understanding of the transcriptional network that maintains pluripotency in mouse ES cells.
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页码：360 / 372
页数：12
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[1]  
Solter D(2006)From teratocarcinomas to embryonic stem cells and beyond: a history of embryonic stem cell research Nat Rev Genet 7 319-327
[2]  
Martin GR(1981)Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells Proc Natl Acad Sci USA 78 7634-7638
[3]  
Evans MJ(1981)Establishment in culture of pluripotential cells from mouse embryos Nature 292 154-156
[4]  
Kaufman MH(2007)Derivation of pluripotent epiblast stem cells from mammalian embryos Nature 448 191-195
[5]  
Brons IG(2007)New cell lines from mouse epiblast share defining features with human embryonic stem cells Nature 448 196-199
[6]  
Smithers LE(1998)Embryonic stem cell lines derived from human blastocysts Science 282 1145-1147
[7]  
Trotter MW(2009)Klf4 reverts developmentally programmed restriction of ground state pluripotency Development 136 1063-1069
[8]  
Tesar PJ(2008)The growth factor environment defines distinct pluripotent ground states in novel blastocyst-derived stem cells Cell 135 449-461
[9]  
Chenoweth JG(2004)A novel mechanism for regulating clonal propagation of mouse ES cells Genes Cells 9 471-477
[10]  
Brook FA(2009)BNP signaling is crucial for embryonic stem cell proliferation PLoS ONE 4 e5341-464
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