BRCA1 and BRCA2– breast cancer susceptibility genes

被引：0

作者：

W. Hofmann

P. M. Schlag

机构：

[1] Department of Tumor Genetics,

[2] Max Delbrück Center for Molecular Medicine,undefined

[3] Robert-Rössle-Str. 10,undefined

[4] D-13092 Berlin,undefined

[5] Germany,undefined

[6] Department of Surgery and Surgical Oncology,undefined

[7] Robert Roessle Hospital,undefined

[8] Lindenberger Weg 80,undefined

[9] D-13122 Berlin,undefined

[10] Germany Tel.: +49-30-9417-1400 Fax: +49-30-9417-1404,undefined

来源：

Journal of Cancer Research and Clinical Oncology | 2000年 / 126卷

关键词：

Key wordsBRCA1; BRCA2; Breast cancer; Genetic predisposition;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Genetic predisposition is responsible for 5%–10% of all breast cancer cases. Therefore, the inherited susceptibility to breast cancer has been intensively investigated during the last 10 years. In particular, the identification of the breast cancer susceptibility genes BRCA1 (breast cancer gene 1) and BRCA2 and the current genetic testing for mutations in both genes are the basis for estimating disease risks for women with a strong family history of breast cancer and will provide important information on the prevention and treatment of familial breast cancer.

引用

页码：487 / 496

页数：9