Calcium dependent plasticity applied to repetitive transcranial magnetic stimulation with a neural field model

被引：0
作者：
M. T. Wilson
P. K. Fung
P. A. Robinson
J. Shemmell
J. N. J. Reynolds
机构：
[1] University of Waikato,School of Engineering, Faculty of Science and Engineering
[2] University of Otago,School of Physical Education, Brain Health Research Centre
[3] University of Otago School of Medical Sciences,Department of Anatomy, Brain Health Research Centre
[4] Department of Ophthalmology,School of Physics
[5] SUNY Downstate Medical Center,Center for Integrative Brain Function
[6] University of Sydney,undefined
[7] University of Sydney,undefined
[8] Center for Research Excellence,undefined
[9] NeuroSleep,undefined
来源：
Journal of Computational Neuroscience | 2016年 / 41卷
关键词：
Transcranial magnetic stimulation; Calcium dependent plasticity; Modeling; Theta burst stimulation; Neural field theory;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The calcium dependent plasticity (CaDP) approach to the modeling of synaptic weight change is applied using a neural field approach to realistic repetitive transcranial magnetic stimulation (rTMS) protocols. A spatially-symmetric nonlinear neural field model consisting of populations of excitatory and inhibitory neurons is used. The plasticity between excitatory cell populations is then evaluated using a CaDP approach that incorporates metaplasticity. The direction and size of the plasticity (potentiation or depression) depends on both the amplitude of stimulation and duration of the protocol. The breaks in the inhibitory theta-burst stimulation protocol are crucial to ensuring that the stimulation bursts are potentiating in nature. Tuning the parameters of a spike-timing dependent plasticity (STDP) window with a Monte Carlo approach to maximize agreement between STDP predictions and the CaDP results reproduces a realistically-shaped window with two regions of depression in agreement with the existing literature. Developing understanding of how TMS interacts with cells at a network level may be important for future investigation.
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页码：107 / 125
页数：18
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