Fast and accurate long-read assembly with wtdbg2

被引：0
作者：
Jue Ruan
Heng Li
机构：
[1] Agricultural Genomics Institute,Department of Data Sciences
[2] Chinese Academy of Agriculture Sciences,Department of Biomedical Informatics
[3] Peng Cheng Laboratory,undefined
[4] Dana-Farber Cancer Institute,undefined
[5] Harvard Medical School,undefined
[6] Broad Institute,undefined
来源：
Nature Methods | 2020年 / 17卷
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学科分类号：
摘要：
Existing long-read assemblers require thousands of central processing unit hours to assemble a human genome and are being outpaced by sequencing technologies in terms of both throughput and cost. We developed a long-read assembler wtdbg2 (https://github.com/ruanjue/wtdbg2) that is 2–17 times as fast as published tools while achieving comparable contiguity and accuracy. It paves the way for population-scale long-read assembly in future.
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页码：155 / 158
页数：3
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