The role of miRNAs in the diagnosis and treatment of male infertility: a review study

被引:0
作者
Roya Sinaei
Khosro Jamebozorgi
Hossein Mirshekarpour
Hossein Poormasoumi
Amirhossein Mahdizadeh
Zahra Akbari
Eskandar Taghizadeh
机构
[1] Islamic Azad University,Department of Genetics, Tehran Medical Sciences
[2] Zabol University of Medical Sciences,Faculty of Medicine
[3] Kerman University of Medical Sciences,Nuclear Medicine of Shafa Hospital
[4] Ahvaz Jundishapur University of Medical Sciences,Department of Medical Genetics, Faculty of Medicine
[5] Ahvaz Jundishapur University of Medical Sciences,Department of Periodontics, School of Dentistry
来源
Egyptian Journal of Medical Human Genetics | / 24卷
关键词
MiRNA; Biomarkers; Male infertility; Diagnosis; Therapeutics;
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摘要
Infertility is a widespread issue that affects over five million couples globally. The cause of this condition can be related to women, men, or both. Male infertility, as a clinical disorder, can be caused by problems in spermatogenesis, testicular development, epididymal, and sperm maturation. Various methods have been proposed to diagnose and treat this disorder, but in some cases, it still remains idiopathic. Nowadays, the investigation of miRNAs is being discussed for the diagnosis and treatment of male infertility. miRNAs are small non-coding RNAs that regulate the expression of many genes after transcription. The aim of this review is to study miRNAs as noninvasive biomarkers for the diagnosis of infertility, as well as proposed treatment strategies and the challenges ahead in these avenues.
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