Emergence and spread of two SARS-CoV-2 variants of interest in Nigeria

被引：0

作者：

Idowu B. Olawoye

Paul E. Oluniyi

Judith U. Oguzie

Jessica N. Uwanibe

Tolulope A. Kayode

Testimony J. Olumade

Fehintola V. Ajogbasile

Edyth Parker

Philomena E. Eromon

Priscilla Abechi

Tope A. Sobajo

Chinedu A. Ugwu

Uwem E. George

Femi Ayoade

Kazeem Akano

Nicholas E. Oyejide

Iguosadolo Nosamiefan

Iyanuoluwa Fred-Akintunwa

Kemi Adedotun-Sulaiman

Farida B. Brimmo

Babatunde B. Adegboyega

Courage Philip

Richard A. Adeleke

Grace C. Chukwu

Muhammad I. Ahmed

Oludayo O. Ope-Ewe

Shobi G. Otitoola

Olusola A. Ogunsanya

Mudasiru F. Saibu

Ayotunde E. Sijuwola

Grace O. Ezekiel

Oluwagboadurami G. John

Julie O. Akin-John

Oluwasemilogo O. Akinlo

Olanrewaju O. Fayemi

Testimony O. Ipaye

Deborah C. Nwodo

Abolade E. Omoniyi

Iyobosa B. Omwanghe

Christabel A. Terkuma

Johnson Okolie

Olubukola Ayo-Ale

Odia Ikponmwosa

Ebo Benevolence

Grace O. Naregose

Akhilomen E. Patience

Osiemi Blessing

Airende Micheal

Agbukor Jacqueline

John O. Aiyepada

机构：

[1] Redeemer’s University,Department of Biological Sciences, Faculty of Natural Sciences

[2] Redeemer’s University,African Centre of Excellence for Genomics of Infectious Diseases (ACEGID)

[3] The Scripps Research Institute,Department of Immunology and Microbiology

[4] Irrua Specialist Teaching Hospital,Department of Medical Laboratory Science

[5] Niger Delta University,Satellite Molecular Laboratory

[6] Rivers State University Teaching Hospital,Molecular Laboratory, Regional Centre for Biotechnology and Bioresources Research

[7] The Nigerian Institute of Medical Research,Department of Medical Microbiology and Parasitology

[8] University of Port Harcourt,Department of Public Health

[9] Family Physician,WHO Polio Laboratory

[10] SPDC,Department of Immunology

[11] Clinical Health,Department of Community Medicine

[12] SPDC,Department of Medical Microbiology and Parasitology. Faculty of Basic Clinical Sciences. College of Health Sciences

[13] Regional Community Health,Medical Microbiology and Parasitology Department, College of Medicine

[14] SPDC,Biorepository Clinical Virology Laboratory

[15] Occupational Health,Virology Laboratory

[16] SPDC,Department of Medicine

[17] University of Uyo,Internal Medicine Department

[18] Rivers State University,Haematology Department

[19] Ministry of Health,Department of Medical Microbiology

[20] University of Maiduguri Teaching Hospital,Department of Epidemiology and Community Health, Faculty of Clinical Sciences, College of Health Sciences

[21] University of Maiduguri Teaching Hospital,Department of Immunology and Infectious Diseases

[22] University of Maiduguri Teaching Hospital,undefined

[23] University of Ilorin,undefined

[24] Nigeria Centre for Disease Control,undefined

[25] University of Ibadan,undefined

[26] University of Ibadan,undefined

[27] Alex Ekwueme Federal University Teaching Hospital,undefined

[28] Alex Ekwueme Federal University Teaching Hospital,undefined

[29] University of Toronto,undefined

[30] BlueDot,undefined

[31] Alex Ekwueme Federal University Teaching Hospital,undefined

[32] Alex Ekwueme Federal University Teaching Hospital,undefined

[33] Federal Medical Center,undefined

[34] Ministry of Health,undefined

[35] University of Maiduguri Teaching Hospital,undefined

[36] Broad Institute of Harvard and MIT,undefined

[37] University of Ilorin,undefined

[38] Harvard TH Chan School of Public Health,undefined

来源：

Nature Communications | / 14卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Identifying the dissemination patterns and impacts of a virus of economic or health importance during a pandemic is crucial, as it informs the public on policies for containment in order to reduce the spread of the virus. In this study, we integrated genomic and travel data to investigate the emergence and spread of the SARS-CoV-2 B.1.1.318 and B.1.525 (Eta) variants of interest in Nigeria and the wider Africa region. By integrating travel data and phylogeographic reconstructions, we find that these two variants that arose during the second wave in Nigeria emerged from within Africa, with the B.1.525 from Nigeria, and then spread to other parts of the world. Data from this study show how regional connectivity of Nigeria drove the spread of these variants of interest to surrounding countries and those connected by air-traffic. Our findings demonstrate the power of genomic analysis when combined with mobility and epidemiological data to identify the drivers of transmission, as bidirectional transmission within and between African nations are grossly underestimated as seen in our import risk index estimates.

引用

共 69 条

[1]

Tessema SK(2021)Understanding COVID-19 in Africa Nat. Rev. Immunol. 21 469-470

[2]

Nkengasong JN(2020)Preparedness and vulnerability of African countries against importations of COVID-19: a modelling study Lancet 395 871-877

[3]

Gilbert M(2021)Cross-reactive antibodies to SARS-CoV-2 and MERS-CoV in pre-COVID-19 blood samples from Sierra Leoneans Viruses 13 2325-1101

[4]

Borrega R(2021)Emergence and spread of a SARS-CoV-2 lineage A variant (A. 23.1) with altered spike protein in Uganda Nat. Microbiol. 6 1094-1

[5]

Bugembe DL(2021)Genomic sequencing of SARS-CoV-2 in Rwanda reveals the importance of incoming travelers on lineage diversity Nat. Commun. 12 1-31.

[6]

Butera Y(2021)A year of genomic surveillance reveals how the SARS-CoV-2 pandemic unfolded in Africa Science 374 423-4

[7]

Wilkinson E(2022)Regional connectivity drove bidirectional transmission of SARS-CoV-2 in the Middle East during travel restrictions Nat. Commun. 13 1-35

[8]

Parker E(2015)Assessment of the potential for international dissemination of Ebola virus via commercial air travel during the 2014 west African outbreak Lancet 385 29-43.

[9]

Bogoch II(2021)Detection of a SARS-CoV-2 variant of concern in South Africa Nature 592 438-686

[10]

Tegally H(2022)Rapid epidemic expansion of the SARS-CoV-2 Omicron variant in southern Africa Nature 603 679-5526

← 1 2 3 4 5 6 7 →